Dissecting diagnostic heterogeneity in depression by integrating neuroimaging and genetics
AM Buch, C Liston - Neuropsychopharmacology, 2021 - nature.com
Depression is a heterogeneous and etiologically complex psychiatric syndrome, not a
unitary disease entity, encompassing a broad spectrum of psychopathology arising from …
unitary disease entity, encompassing a broad spectrum of psychopathology arising from …
[HTML][HTML] Functional dysconnectivity in youth depression: Systematic review, meta‐analysis, and network-based integration
Youth depression has been associated with heterogenous patterns of aberrant brain
connectivity. To make sense of these divergent findings, we conducted a systematic review …
connectivity. To make sense of these divergent findings, we conducted a systematic review …
Predictive modeling of depression and anxiety using electronic health records and a novel machine learning approach with artificial intelligence
Generalized anxiety disorder (GAD) and major depressive disorder (MDD) are highly
prevalent and impairing problems, but frequently go undetected, leading to substantial …
prevalent and impairing problems, but frequently go undetected, leading to substantial …
Stress to inflammation and anhedonia: Mechanistic insights from preclinical and clinical models
Anhedonia, as evidenced by impaired pleasurable response to reward, reduced reward
motivation, and/or deficits in reward-related learning, is a common feature of depression …
motivation, and/or deficits in reward-related learning, is a common feature of depression …
Annual research review: emotion processing in offspring of mothers with depression diagnoses–a systematic review of neural and physiological research
KL Burkhouse, A Kujawa - Journal of Child Psychology and …, 2023 - Wiley Online Library
Background Theories of the intergenerational transmission of depression emphasize
alterations in emotion processing among offspring of depressed mothers as a key risk …
alterations in emotion processing among offspring of depressed mothers as a key risk …
[HTML][HTML] Reward versus nonreward sensitivity of the medial versus lateral orbitofrontal cortex relates to the severity of depressive symptoms
Background The orbitofrontal cortex (OFC) is implicated in depression. The hypothesis
investigated was whether the OFC sensitivity to reward and nonreward is related to the …
investigated was whether the OFC sensitivity to reward and nonreward is related to the …
Brain morphometry and connectivity differs between adolescent‐and adult‐onset major depressive disorder
Background Early‐onset (EO) major depressive disorder (MDD) patients experience more
depressive episodes and an increased risk of relapse. Thus, on a neurobiological level …
depressive episodes and an increased risk of relapse. Thus, on a neurobiological level …
Resting state functional connectivity as a marker of internalizing disorder onset in high-risk youth
MK Pawlak, S Bray, DC Kopala-Sibley - Scientific Reports, 2022 - nature.com
While research has linked alterations in functional connectivity of the default mode (DMN),
cognitive control (CCN), and salience networks (SN) to depression and anxiety, little …
cognitive control (CCN), and salience networks (SN) to depression and anxiety, little …
Multiple domains of risk factors for first onset of depression in adolescent girls
Background: First onsets of depression are especially common in adolescent females and
often develop into chronic/recurrent illness. Surprisingly few studies have comprehensively …
often develop into chronic/recurrent illness. Surprisingly few studies have comprehensively …
[HTML][HTML] Neural markers of familial risk for depression–A systematic review
Structural and functional brain alterations are found in adults with depression. It is not known
whether these changes are a result of illness or exist prior to disorder onset. Asymptomatic …
whether these changes are a result of illness or exist prior to disorder onset. Asymptomatic …