Oxidative stress and inflammation in COVID-19-associated sepsis: the potential role of anti-oxidant therapy in avoiding disease progression

J Beltrán-García, R Osca-Verdegal, FV Pallardó… - Antioxidants, 2020 - mdpi.com
Since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak
emerged, countless efforts are being made worldwide to understand the molecular …

Coronaviruses exploit a host cysteine-aspartic protease for replication

H Chu, Y Hou, D Yang, L Wen, H Shuai, C Yoon, J Shi… - Nature, 2022 - nature.com
Highly pathogenic coronaviruses, including severe acute respiratory syndrome coronavirus
2 (refs.,)(SARS-CoV-2), Middle East respiratory syndrome coronavirus (MERS-CoV) and …

COVID-19, cytokines, inflammation, and spices: How are they related?

AB Kunnumakkara, V Rana, D Parama, K Banik… - Life sciences, 2021 - Elsevier
Background Cytokine storm is the exaggerated immune response often observed in viral
infections. It is also intimately linked with the progression of COVID-19 disease as well as …

The roles of critical pro‐inflammatory cytokines in the drive of cytokine storm during SARS‐CoV‐2 infection

MS Qudus, M Tian, S Sirajuddin, S Liu… - Journal of Medical …, 2023 - Wiley Online Library
In patients with severe COVID‐19, acute respiratory distress syndrome (ARDS), multiple
organ dysfunction syndrome (MODS), and even mortality can result from cytokine storm …

Innate immunity, cytokine storm, and inflammatory cell death in COVID-19

R Karki, TD Kanneganti - Journal of Translational Medicine, 2022 - Springer
The innate immune system serves as the first line of defense against invading pathogens;
however, dysregulated innate immune responses can induce aberrant inflammation that is …

SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation

G Xu, Y Li, S Zhang, H Peng, Y Wang, D Li, T Jin, Z He… - Cell research, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is the ongoing global pandemic that poses …

The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication

Q Ning, D Wu, X Wang, D Xi, T Chen, G Chen… - Signal transduction and …, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) is a highly transmissible disease
caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a …

Lymphopenia an important immunological abnormality in patients with COVID‐19: possible mechanisms

A Jafarzadeh, S Jafarzadeh, P Nozari… - Scandinavian …, 2021 - Wiley Online Library
The lymphopenia as a major immunological abnormality occurs in the majority of severe
COVID‐19 patients, which is strongly associated with mortality rate. A low proportion of …

[HTML][HTML] CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14

BK Patterson, H Seethamraju, K Dhody… - International Journal of …, 2021 - Elsevier
Objective Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is
now a global pandemic. Emerging results indicate a dysregulated immune response. Given …

The cytokine storm in COVID-19: Further advances in our understanding the role of specific chemokines involved

F Coperchini, L Chiovato, G Ricci, L Croce… - Cytokine & Growth …, 2021 - Elsevier
SARS-COV-2 infection represents the greatest pandemic of the world, counting daily
increasing number of subjects positive to the virus and, sadly, increasing number of deaths …