SARS-CoV-2 in immunocompromised individuals

S DeWolf, JC Laracy, MA Perales, M Kamboj… - Immunity, 2022 - cell.com
Immunocompromised individuals and particularly those with hematologic malignancies are
at increased risk for SARS-CoV-2-associated morbidity and mortality due to immunologic …

[HTML][HTML] Extended SARS-CoV-2 RBD booster vaccination induces humoral and cellular immune tolerance in mice

FX Gao, RX Wu, MY Shen, JJ Huang, TT Li, C Hu… - Iscience, 2022 - cell.com
The repetitive applications of vaccine boosters have been brought up in face of continuous
emergence of SARS-CoV-2 variants with neutralization escape mutations, but their …

SARS-CoV-2 pre-exposure prophylaxis: A potential COVID-19 preventive strategy for high-risk populations, including healthcare workers, immunodeficient individuals …

J Ouyang, SD Zaongo, V Harypursat, X Li… - Frontiers in Public …, 2022 - frontiersin.org
The unprecedented worldwide spread of SARS-CoV-2 has imposed severe challenges on
global health care systems. The roll-out and widespread administration of COVID-19 …

新型冠状病毒感染脆弱人群的识别及防治展望

郑劲平, 薛武军, 巨春蓉, 马军, 曾小峰 - 中国全科医学, 2024 - chinagp.net
新型冠状病毒感染疫情对人类健康和全球经济造成重创. 健康相关脆弱人群的免疫功能减退,
导致疫苗的防护效果不足, 并且, 感染新型冠状病毒后重症和死亡风险更高, 而目前尚缺乏足够有 …

RBD-specific Th1 responses are associated with vaccine-induced protection against SARS-CoV-2 infection in patients with hematological malignancies

C Bigenwald, Y Haddad, C Thelemaque… - …, 2023 - Taylor & Francis
The SARS-CoV-2 pandemic still represents a threat for immunosuppressed and
hematological malignancy (HM) bearing patients, causing increased morbidity and mortality …

Peripheral lymphocyte subset counts predict antibody response after SARS-CoV-2 mRNA-BNT162b2 vaccine in cancer patients: Results from the Vax-On-Profile …

F Nelli, A Fabbri, V Panichi, D Giannarelli… - International …, 2022 - Elsevier
Background The adaptive immune response following COVID-19 vaccination is essential for
humoral immunogenicity and clinical protection against symptomatic infections. We present …

Higher pro‐inflammatory cytokines IL‐6 and IFN‐γ are associated with anti‐SARS‐CoV‐2 spike protein‐specific seroconversion in renal allograft recipients

B Yadav, N Prasad, RS Kushwaha… - Transplant Infectious …, 2023 - Wiley Online Library
Background Maintenance immunosuppressive regimens are speculated to hamper
immunogenic response against severe acute respiratory syndrome‐coronavirus‐2 (SARS …

Combining SARS‐CoV‐2 interferon‐gamma release assay with humoral response assessment to define immune memory profiles

W Mouton, G Oriol, C Compagnon… - European Journal of …, 2024 - Wiley Online Library
Objectives In the post‐SARS‐CoV‐2 pandemic era,“breakthrough infections” are still
documented, due to variants of concerns (VoCs) emergence and waning humoral immunity …

Conserved longitudinal alterations of anti-s-protein IgG subclasses in disease progression in initial ancestral wuhan and vaccine breakthrough delta infections

YS Goh, SW Fong, PX Hor, SN Amrun… - Frontiers in …, 2022 - frontiersin.org
Introduction COVID-19 has a wide disease spectrum ranging from asymptomatic to severe.
While humoral immune responses are critical in preventing infection, the immune …

Identification of COVID-19 Infection in Vulnerable Population and Its Prevention and Treatment Perspectives

J ZHENG, W XUE, C JU, J MA, X ZENG - Chinese General Practice, 2024 - chinagp.net
The COVID-19 pandemic has devastated human health and global economy. Diminished
immune function of health-related vulnerable populations leads to insufficient protective …