The introduction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the
human population represents a tremendous medical and economic crisis. Innate immunity …

Vaccination has been a game changer in our efforts to address the coronavirus disease
2019 (COVID-19) pandemic. However, the disease might still represent a clinical crisis for …

Background COVID-19 is a multisystemic disorder that frequently causes acute kidney injury
(AKI). However, the precise clinical and biochemical variables associated with AKI …

Abstract Monocyte Distribution Width (MDW), a new cytometric parameter correlating with
cytomorphologic changes occurring upon massive monocyte activation, has recently …

Objective Histone proteins are physiologically involved in DNA packaging and gene
regulation but are extracellularly released by neutrophil/monocyte extracellular traps and …

The utilization of host-cell machinery during SARS-CoV-2 infection can overwhelm the
protein-folding capacity of the endoplasmic reticulum and activate the unfolded protein …

Background: Antipsychotics modulate expression of inflammatory cytokines and inducible
inflammatory enzymes. Elopiprazole (a phenylpiperazine antipsychotic drug in phase 1) has …

We read with great interest the article of Bendib et al. published in Critical Care [1], in which
they systematically assessed inflammatory mediators in pneumoniarelated ARDS, both in …

Hematological and hemorheological parameters are known to be altered in COVID-19;
however, the value of combined monitoring in order to deduce disease severity is only …

Background The pathogenesis of coronavirus disease 2019 (COVID-19) is characterized by
enhanced platelet activation and diffuse hemostatic alterations, which may contribute to …