The goal of this review article is to provide a resource for longitudinal studies, using animal
models, directed at understanding and modifying the relationship between cognition and …

Synaptic plasticity configures interactions between neurons and is therefore likely to be a
primary driver of behavioral learning and development. How this microscopic-macroscopic …

A fundamental challenge in developing treatments for autism spectrum disorders is the
heterogeneity of the condition. More than one hundred genetic mutations confer high risk for …

Transcriptional silencing of the FMR1 gene in fragile X syndrome (FXS) leads to the loss of
the RNA-binding protein FMRP. In addition to regulating mRNA translation and protein …

Autism spectrum disorder (ASD) is a multifactorial disorder with characteristic synaptic and
gene expression changes. Early intervention during childhood is thought to benefit …

Cellular hyperexcitability is a salient feature of fragile X syndrome animal models. The
cellular basis of hyperexcitability and how it responds to changing activity states is not fully …

Cholesterol is an essential membrane structural component and steroid hormone precursor,
and is involved in numerous signaling processes. Astrocytes regulate brain cholesterol …

The fragile X-related disorders are an important group of hereditary disorders that are
caused by expanded CGG repeats in the 5′ untranslated region of the FMR1 gene or by …

Fragile X syndrome (FXS) is an inherited form of intellectual disability caused by the loss of
the mRNA-binding fragile X mental retardation protein (FMRP). FXS is characterized by …

Fragile X syndrome is caused by FMR1 gene silencing and loss of the encoded fragile X
mental retardation protein (FMRP), which binds to mRNA and regulates translation. Studies …