Tumor necrosis factor α (TNF) is a potent pro-inflammatory cytokine that has deleterious
effect in some autoimmune diseases, which led to the use of anti-TNF drugs in some of …

Acute graft-versus-host disease (GVHD) occurs after allogeneic hematopoietic stem cell
transplant and is a reaction of donor immune cells against host tissues. Activated donor T …

Cytokine storm is an acute hyperinflammatory response that may be responsible for critical
illness in many conditions including viral infections, cancer, sepsis, and multi-organ failure …

Destruction of the host intestinal epithelium by donor effector T cell populations is a hallmark
of graft-versus-host disease (GVHD), but the underlying mechanisms remain obscure. We …

Goals of work Despite advances in allogeneic hematopoietic stem cell transplantation
(HSCT), post-transplant complications are common, and patients' symptom experience has …

Hematopoietic stem cell transplantation has evolved as a central treatment modality in the
management of different hematologic malignancies. Despite adequate posttransplantation …

Acute graft-versus-host disease (GVHD) is one of the major complications of hematopoietic
stem cell transplantation. Many variables including stem cell source, age of donor and …

Lymphodepletion with chemotherapeutic agents or total body irradiation (TBI) before
adoptive transfer of tumor-specific T cells is a critical advancement in the treatment of …

The inhibition of inflammation-associated angiogenesis ameliorates inflammatory diseases
by reducing the recruitment of tissue-infiltrating leukocytes. However, it is not known if …

Clinical graft-versus-host disease (GVHD) symptoms are the result of a complex set of
interactions between cellular and soluble factors. One of the key soluble factors is the …