Minor histocompatibility antigens (mHags) play an important role in both graft-versus-tumor
effects and graft-versus-host disease (GVHD) after allogeneic stem cell transplantation. We …

Animal disease models have been criticized for lack of resemblance to human illnesses,
hampering transfer of knowledge from preclinical research to clinical medicine. In the field of …

Graft-versus-host disease (GvHD) in its acute and chronic forms continues to represent a
significant barrier to the success and wide-applicability of blood and marrow transplantation …

The difficult separation of clinical graft-versus-tumor (GVT) effects from graft-versus-host
disease (GVHD) reflects their shared biology. Experimental approaches to mediate GVT …

In a mouse model, inflammatory cytokines play a primary role in the development of acute
graft-versus-host disease (aGVHD). Here, we retrospectively evaluated whether the …

Peripheral blood T cells were isolated from 19 allogeneic and 4 autologous stem cell
transplant (SCT) recipients and assessed for tumor necrosis factor (TNF)–α and interferon …

Graft-versus-host disease and disease relapse are the 2 major causes of failure of
allogeneic hematopoietic stem cell transplantation (SCT). Ideally, patients who undergo …

Abstract Vizantin, 6, 6′-bis-O-(3-nonyldodecanoyl)-α, α′-trehalose, has been developed
as a safe immunostimulator on the basis of a structure–activity relationship study with …

The primary objective of this clinical trial was to evaluate the safety, feasibility, and biologic
effects of administering costimulated, interleukin (IL)-4 polarized donor CD4+ T cells in the …

Introduction: Graft‐versus‐host disease (GVHD) is a serious complication of bone marrow
transplantation (BMT), requiring higher doses of glucocorticoids or immunosuppressive …