The signal pathways and treatment of cytokine storm in COVID-19
L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - Signal transduction and …, 2021 - nature.com
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has become a global crisis
and is more devastating than any other previous infectious disease. It has affected a …
and is more devastating than any other previous infectious disease. It has affected a …
Host-directed immunotherapy of viral and bacterial infections: past, present and future
The advent of COVID-19 and the persistent threat of infectious diseases such as
tuberculosis, malaria, influenza and HIV/AIDS remind us of the marked impact that infections …
tuberculosis, malaria, influenza and HIV/AIDS remind us of the marked impact that infections …
Genetic mechanisms of critical illness in COVID-19
Host-mediated lung inflammation is present, and drives mortality, in the critical illness
caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with …
caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with …
Cytokine storm
DC Fajgenbaum, CH June - New England Journal of Medicine, 2020 - Mass Medical Soc
Cytokine Storm Cytokine storm, a life-threatening disorder involving cytokine elevations and
immune-cell hyperactivation, has various causes and is characterized by constitutional …
immune-cell hyperactivation, has various causes and is characterized by constitutional …
Infectious Diseases Society of America Guidelines on the treatment and management of patients with coronavirus disease 2019 (COVID-19)
Background There are many pharmacologic therapies that are being used or considered for
treatment of coronavirus disease 2019 (COVID-19). There is a need for frequently updated …
treatment of coronavirus disease 2019 (COVID-19). There is a need for frequently updated …
Tissue-specific immunopathology in fatal COVID-19
Rationale: In life-threatening coronavirus disease (COVID-19), corticosteroids reduce
mortality, suggesting that immune responses have a causal role in death. Whether this …
mortality, suggesting that immune responses have a causal role in death. Whether this …
Methylprednisolone as adjunctive therapy for patients hospitalized with coronavirus disease 2019 (COVID-19; Metcovid): a randomized, double-blind, phase IIb …
CMP Jeronimo, MEL Farias, FFA Val… - Clinical Infectious …, 2021 - academic.oup.com
Background Steroid use for coronavirus disease 2019 (COVID-19) is based on the possible
role of these drugs in mitigating the inflammatory response, mainly in the lungs, triggered by …
role of these drugs in mitigating the inflammatory response, mainly in the lungs, triggered by …
Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19
RS Thwaites, A Sanchez Sevilla Uruchurtu… - Science …, 2021 - science.org
While it is now widely accepted that host inflammatory responses contribute to lung injury,
the pathways that drive severity and distinguish coronavirus disease 2019 (COVID-19) from …
the pathways that drive severity and distinguish coronavirus disease 2019 (COVID-19) from …
[HTML][HTML] Efficacy and safety of tocilizumab in COVID-19 patients: a living systematic review and meta-analysis
IM Tleyjeh, Z Kashour, M Damlaj, M Riaz… - Clinical Microbiology …, 2021 - Elsevier
Objectives Cytokine release syndrome with elevated interleukin-6 (IL-6) levels is associated
with multiorgan damage and death in severe coronavirus disease 2019 (COVID-19). Our …
with multiorgan damage and death in severe coronavirus disease 2019 (COVID-19). Our …
The drug repurposing for COVID-19 clinical trials provide very effective therapeutic combinations: lessons learned from major clinical studies
SARS-CoV-2 has spread across the globe in no time. In the beginning, people suffered due
to the absence of efficacious drugs required to treat severely ill patients. Nevertheless, still …
to the absence of efficacious drugs required to treat severely ill patients. Nevertheless, still …