In the wake of the COVID-19 crisis, a need has arisen to prevent and treat two related
conditions, COVID-19 vaccine injury and long COVID-19, both of which can trace at least …

Serine proteases are members of a large family of hydrolytic enzymes in which a particular
serine residue in the active site performs an essential role as a nucleophile, which is …

Host cell proteases such as TMPRSS2 are critical determinants of severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2) tropism and pathogenesis. Here, we show that …

Alpha-1-antitrypsin (AAT), a serine protease inhibitor (serpin), is increasingly recognized to
inhibit SARS-CoV-2 infection and counter many of the pathogenic mechanisms of COVID …

SARS-CoV-2 initially infects cells in the nasopharynx and oral cavity. The immune system at
these mucosal sites plays a crucial role in minimizing viral transmission and infection. To …

The human genome is estimated to encode more than 500 proteases performing a wide
range of important physiological functions. They digest proteins in our food, determine the …

The COVID-19 pandemic has highlighted the need for new antiviral approaches because
many of the currently approved drugs have proven ineffective against mitigating SARS-CoV …

Serpins are a superfamily of proteins that regulate a variety of physiological processes by
irreversibly inhibiting the enzymatic activity of different serine proteases. For example …

Understanding the dynamic changes in gene expression during Acute Respiratory Distress
Syndrome (ARDS) progression in post-acute infection patients is crucial for unraveling the …

Introduction Serine proteases play a critical role during SARS-CoV-2 infection. Therefore,
polymorphisms of transmembrane protease serine 2 (TMPRSS2) and serpine family E …