Synthetic manipulation of the cancer-immunity cycle: CAR-T cell therapy
Synthetic immunity to cancer has been pioneered by the application of chimeric antigen
receptor (CAR) engineering into autologous T cells. CAR T cell therapy is highly amenable …
receptor (CAR) engineering into autologous T cells. CAR T cell therapy is highly amenable …
Chromatin remodellers as therapeutic targets
HA Malone, CWM Roberts - Nature Reviews Drug Discovery, 2024 - nature.com
Large-scale cancer genome sequencing studies have revealed that chromatin regulators
are frequently mutated in cancer. In particular, more than 20% of cancers harbour mutations …
are frequently mutated in cancer. In particular, more than 20% of cancers harbour mutations …
Canonical BAF complex activity shapes the enhancer landscape that licenses CD8+ T cell effector and memory fates
CD8+ T cells provide host protection against pathogens by differentiating into distinct
effector and memory cell subsets, but how chromatin is site-specifically remodeled during …
effector and memory cell subsets, but how chromatin is site-specifically remodeled during …
[HTML][HTML] Targeting the mSWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies
Summary The POU2F3-POU2AF2/3 transcription factor complex is the master regulator of
the tuft cell lineage and tuft cell-like small cell lung cancer (SCLC). Here, we identify a …
the tuft cell lineage and tuft cell-like small cell lung cancer (SCLC). Here, we identify a …
Dysregulation in IFN-γ signaling and response: the barricade to tumor immunotherapy
J Han, M Wu, Z Liu - Frontiers in Immunology, 2023 - frontiersin.org
Interferon-gamma (IFN-γ) has been identified as a crucial factor in determining the
responsiveness to immunotherapy. Produced primarily by natural killer (NK) and T cells, IFN …
responsiveness to immunotherapy. Produced primarily by natural killer (NK) and T cells, IFN …
The cytokine Meteorin-like inhibits anti-tumor CD8+ T cell responses by disrupting mitochondrial function
Tumor-infiltrating lymphocyte (TIL) hypofunction contributes to the progression of advanced
cancers and is a frequent target of immunotherapy. Emerging evidence indicates that …
cancers and is a frequent target of immunotherapy. Emerging evidence indicates that …
T cell exhaustion in human cancers
K Kang, X Lin, P Chen, H Liu, F Liu, W Xiong… - … et Biophysica Acta (BBA …, 2024 - Elsevier
T cell exhaustion refers to a progressive state in which T cells become functionally impaired
due to sustained antigenic stimulation, which is characterized by increased expression of …
due to sustained antigenic stimulation, which is characterized by increased expression of …
YTHDF2 upregulation and subcellular localization dictate CD8 T cell polyfunctionality in anti-tumor immunity
H Zhang, X Luo, W Yang, Z Wu, Z Zhao, X Pei… - Nature …, 2024 - nature.com
RNA methylation is an important regulatory process to determine immune cell function but
how it affects the anti-tumor activity of CD8 T cells is not fully understood. Here we show that …
how it affects the anti-tumor activity of CD8 T cells is not fully understood. Here we show that …
Arid1a-dependent canonical BAF complex suppresses inflammatory programs to drive efficient Germinal Center B cell responses
A Abraham, D Samaniego-Castruita, I Han… - Nature …, 2024 - nature.com
Abstract The mammalian Brg1/Brm-associated factor (BAF) complexes are major regulators
of nucleosomal remodeling that are commonly mutated in several cancers, including …
of nucleosomal remodeling that are commonly mutated in several cancers, including …
Egress of resident memory T cells from tissue with neoadjuvant immunotherapy: Implications for systemic anti-tumor immunity
Abstract Introduction Resident memory T (T RM) cells are embedded in peripheral tissue
and capable of acting as sentinels that can respond quickly to repeat pathogen exposure as …
and capable of acting as sentinels that can respond quickly to repeat pathogen exposure as …