Corneal diseases are a leading cause of blindness with an estimated 10 million patients
diagnosed with bilateral corneal blindness worldwide. Corneal transplantation is highly …

Transplantable Tissue—Immune and Genome Engineering Dramatic advancements in the
use of synthetic and mechanical devices to replace tissues have been made, but restoring …

For many patients with terminal/advanced cardiac failure, heart transplantation is the most
effective, durable treatment option, and offers the best prospects for a high quality of life. The …

Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs, and
some of them are able to infect human cells. Therefore, PERVs pose a risk for …

Consistent survival of life-supporting pig heart xenograft recipients beyond 90 days was
recently reported using genetically modified pigs and a clinically applicable drug treatment …

Approximately 65 million adults globally have heart failure, and the prevalence is expected
to increase substantially with ageing populations. Despite advances in pharmacological and …

Cytosine base editors (CBEs) enable programmable C-to-T conversion without DNA double-
stranded breaks and homology-directed repair in a variety of organisms, which exhibit great …

Xenotransplantation using pig organs has achieved survival times up to 195 days in pig
orthotopic heart transplantation into baboons. Here we demonstrate that in addition to an …

Patients awaiting lung transplantation face high wait-list mortality, as injury precludes the
use of most donor lungs. Although ex vivo lung perfusion (EVLP) is able to recover marginal …

Whole-organ pancreas and islet transplantations are performed in a highly selected group of
patients with diabetes mellitus, primarily those with type 1 diabetes mellitus, complicated by …