Differentiated somatic cells can be reprogrammed to totipotent embryos through somatic cell
nuclear transfer (SCNT) with low efficiency. The histone deacetylase inhibitor trichostatin A …

Glioblastoma (GBM) is the most common lethal primary brain cancer in adults. Despite
treatment regimens including surgical resection, radiotherapy, and temozolomide (TMZ) …

The steady progress in genome editing, especially genome editing based on the use of
clustered regularly interspaced short palindromic repeats (CRISPR) and programmable …

Accelerated development of novel CRISPR/Cas9-based genome editing techniques
provides a feasible approach to introduce a variety of precise modifications in the …

Artificial nuclease-dependent DNA cleavage systems (zinc-finger nuclease, ZFN;
transcription activator like effectors, TALENs) and exogenous nucleic acid defense systems …

The advent of base editors (BEs) holds great potential for correcting pathogenic-related
point mutations to treat relevant diseases. However, Cas9 nickase (nCas9)-derived BEs …

Comparative genomics is the comparison of genetic information within and across
organisms to understand the evolution, structure, and function of genes, proteins, and non …

This guidance was developed to summarize current approaches to the potential
transmission of swine-derived organisms to xenograft recipients, health care providers, or …

The advancement in epigenetics research over the past several decades has led to the
potential application of epigenome-editing technologies for the treatment of various …

Incredible strides have been made since the discovery of insulin almost 100 years ago.
Insulin formulations have improved dramatically, glucose levels can be measured …