Hurdles exist to clinical xenotransplantation including potential infectious transmission from
nonhuman species to xenograft recipients. In anticipation of clinical trials of …

To bridge the gap between organ demand and supply, xenotransplantation has long been
considered as a realistic option for end-stage organ failure. Early this year this promise …

Pigs serve as an important agricultural resource and animal model in biomedical studies.
Efficient and precise modification of pig genome by using recently developed gene editing …

Large animals (non-human primates, livestock and dogs) are playing important roles in
biomedical research, and large livestock animals serve as important sources of meat and …

Porcine endogenous retroviruses (PERVs) are present in the genome of all pigs, they infect
certain human cells and therefore pose a special risk for xenotransplantation using pig cells …

Lipotoxicity is a recognized pathological trigger and accelerator of nonalcoholic
steatohepatitis (NASH). However, the molecular basis of lipotoxicity-induced NASH remains …

CRISPR gene editing technology belongs to the third generation of gene editing technology.
Since its discovery, it has attracted the attention of a large number of researchers …

Genome editing, particularly using of site-directed nucleases such as the CRISPR system,
has spread rapidly through the biological sciences. Genome editing in crops could …

To address the ongoing shortage of organs available for replacement, xenotransplantation
of hearts, corneas, skin, and kidneys has been attempted. However, a major obstacle facing …

Facile gene editing has accelerated progress in pig to non-human-primate (NHP) renal
xenotransplantation, however, outcomes are considered inferior to NHP-allotransplantation …