Xenotransplantation has the potential to solve the shortfall of human organ donors.
Genetically modified pigs have been considered as potential animal donors for human …

In recent years, new genome editing technologies have emerged that can edit the genome
of non-human animals with progressively increasing efficiency. Despite ongoing academic …

Various modifications have been performed on biomaterials to improve their applications in
tissue engineering and regenerative medicine. However, the challenges of immunogenicity …

The search for alternatives to allotransplants is driven by the shortage of corneal donors and
is demanding because of the limitations of the alternatives. Indeed, current progress in …

Natural killer (NK) cells play an important role in immune rejection in solid organ
transplantation. To mitigate human NK cell activation in xenotransplantation, introducing …

Pancreas (and islet) transplantation is the only curative treatment for type 1 diabetes patients
whose β-cell functions have been abolished. However, the lack of donor organs has been …

The World Health Organization (WHO) has a long-standing interest in xenotransplantation,
which started with the publication of the “WHO Guidance on Xenogeneic Infection/Disease …

Islet transplantation is a promising long-term, compliance-free, complication-preventing
treatment for type 1 diabetes. However, islet transplantation is currently limited to a narrow …

Targeted nucleases are powerful genomic tools to precisely change the target genome of
living cells, controlling functional genes with high exactness. The clustered regularly …

Advances in genomic sequencing and bioinformatics have led to the prospect of precision
medicine where therapeutics can be advised by the genetic background of individuals. For …