Human allogeneic islet transplantation (ITx) is emerging as a promising treatment option for
qualified patients with type 1 diabetes. However, widespread clinical application of …

Cloning of macaque monkeys by somatic cell nucleus transfer (SCNT) allows the generation
of monkeys with uniform genetic backgrounds that are useful for the development of non …

Pig organ xenotransplantation offers a solution to the shortage of deceased human organs
for transplantation. The pathobiological response to a pig xenograft is complex, involving …

Beta cell replacement has the potential to restore euglycemia in patients with insulin-
dependent diabetes. Although great progress has been made in establishing allogeneic …

The recent pig heart transplant in a patient at the University of Maryland Medical Center has
stimulated renewed interest in the xenotransplantation of organs from genetically …

Despite being time-consuming and costly, generating genome-edited pigs holds great
promise for agricultural, biomedical, and pharmaceutical applications. To further facilitate …

Post‐transplantation infections are common. In immunosuppressed human xenograft
recipients, infection is most likely to be due to the same pathogens seen in human …

The shortage of donor resources has greatly limited the application of clinical
xenotransplantation. As such, genetically engineered pigs are expected to be an ideal organ …

Background Pigs have emerged as one of the most popular large animal models in
biomedical research, which in many cases is considered as a superior choice over rodent …

Abstract Purpose of Review Porcine islets represent a potentially attractive beta-cell source
for xenotransplantation into patients with type 1 diabetes, who are not eligible to islet allo …