Using transgenic silkworms with their natural spinning apparatus has proven to be a
promising way to spin spider silk-like fibers. The challenges are incorporating native-size …

The field of xenotransplantation has fluctuated between great optimism and doubts over the
last 50 years. The initial clinical attempts were extremely ambitious but faced technical and …

Extrachromosomal circular DNA (eccDNA) and ring chromosomes are genetic alterations
found in humans with genetic disorders. However, there is a lack of genetic engineering …

Scientific barriers that have prevented successful xenotransplantation are being breached,
yet many ethical issues remain. Some are broad issues that accompany the adoption of …

Heart transplantation is the only long-lasting lifesaving option for patients with terminal
cardiac failure. The number of available human organs is however far below the actual …

The extreme shortage of human donor organs for treatment of patients with end-stage organ
failures is well known. Xenotransplantation, which might provide unlimited organ supply, is a …

Chronic respiratory diseases remain a major cause of morbidity and mortality worldwide.
The only option at end-stage disease is lung transplantation, but there are not enough donor …

Pigs are an important resource in agriculture and serve as a model for human diseases. Due
to their physiological and anatomical similarities with humans, pigs can recapitulate …

Abstract Purpose of Review The first successful pig to human cardiac xenotransplantation in
January 2022 represented a major step forward in the fields of heart failure, immunology …

As a new genetic engineering technology, gene editing can precisely modify the specific
gene sequence of the organism's genome. In the last 10 years, with the rapid development …