[HTML][HTML] In Vitro, In Silico and Network Pharmacology Mechanistic Approach to Investigate the α-Glucosidase Inhibitors Identified by Q-ToF-LCMS from Phaleria macrocarpa …
The fruit of Phaleria macrocarpa have been traditionally used as an antidiabetic remedy in
Malaysia and neighbouring countries. Despite its potential for diabetes treatment, no …
Malaysia and neighbouring countries. Despite its potential for diabetes treatment, no …
Novel benzochromenes: design, synthesis, cytotoxicity, molecular docking and mechanistic investigations
FG Abdulrahman, HS Abulkhair, RA Zidan… - Future Medicinal …, 2024 - Future Science
Aim: A novel series of fused benzochromenes with expected cytotoxicity and HIF-1α
inhibition was identified. Materials & methods: A bioisosterism-aided approach was applied …
inhibition was identified. Materials & methods: A bioisosterism-aided approach was applied …
[HTML][HTML] A review of typical biological activities of glycyrrhetinic acid and its derivatives
L Chen, J Gong, X Yong, Y Li, S Wang - RSC advances, 2024 - pubs.rsc.org
Glycyrrhetinic acid, a triterpenoid compound primarily sourced from licorice root, exhibits
noteworthy biological attributes, including anti-inflammatory, anti-tumor, antibacterial …
noteworthy biological attributes, including anti-inflammatory, anti-tumor, antibacterial …
Harnessing molecular hybridization approach to discover novel quinoline EGFR-TK inhibitors for cancer treatment
N Ryad, AA Elmaaty, IM Ibrahim… - Future Medicinal …, 2024 - Taylor & Francis
Aim: Using molecular hybridization approach, novel 18 quinoline derivatives (6a–11) were
designed and synthesized as EGFR-TK inhibitors. Materials & methods: The antiproliferative …
designed and synthesized as EGFR-TK inhibitors. Materials & methods: The antiproliferative …
Antiviral activities of olive oil apigenin and taxifolin against SARS-CoV-2 RNA-dependent RNA polymerase (RdRP): In silico, pharmacokinetic, ADMET, and in-vitro …
S Selim, M Albqmi, A Alanazi, Y Alruwaili… - Cogent Food & …, 2023 - Taylor & Francis
A novel coronavirus strain called SARS-CoV-2 first appeared in China in December 2019.
Natural products are significant sources of prospective and new antiviral medications, and …
Natural products are significant sources of prospective and new antiviral medications, and …
Danshensu inhibits SARS-CoV-2 by targeting its main protease as a specific covalent inhibitor and discovery of bifunctional compounds eliciting antiviral and anti …
R Wang, X Chen, H Li, X Chen, D Sun, D Yu… - International Journal of …, 2024 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has posed a serious threat to human. Since there …
syndrome coronavirus 2 (SARS-CoV-2) has posed a serious threat to human. Since there …
LC‐HRMS Profiling and Cytotoxic Potential of Actinomycetes Associated with the Red Sea Soft Coral Sarcophyton glaucum: In vitro and In silico Studies
SS El‐Hawary, MHA Hassan, AO Hudhud… - Chemistry & …, 2024 - Wiley Online Library
In the current study, the actinomycetes associated with the red sea‐derived soft coral
Sarcophyton glaucum were investigated in terms of biological and chemical diversity. Four …
Sarcophyton glaucum were investigated in terms of biological and chemical diversity. Four …
Design, Synthesis of Novel Pyrido [2, 3-d] pyrimidine Derivatives as SARS-CoV-2 Mpro Inhibitors for COVID-19 Therapy
Some of the interesting pyrido [2, 3-d] pyrimidines (3a, 3b), 4,(5a–d),(6a, b), 7–13, and (15a–
c) based on uracil moiety were synthesized efficiently using a conventional method and …
c) based on uracil moiety were synthesized efficiently using a conventional method and …
[HTML][HTML] Phytochemicals for mitigating the COVID-19 crisis: Evidence from pre-clinical and clinical studies
A Das, S Khan, S Roy, S Das - Exploration of Drug Science, 2023 - explorationpub.com
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in
December 2019 quickly escalated to pandemic levels and had a severe impact on public …
December 2019 quickly escalated to pandemic levels and had a severe impact on public …
In Silico Design of an Oseltamivir Derivative with Increased Affinity against Wild‐Type and Mutant Variants of Neuraminidase and Hemagglutinin of Influenza A H1N1 …
GM Jazmin, M Elaheh… - Chemistry & …, 2023 - Wiley Online Library
Antiviral resistance has turned into a world concern nowadays. Influenza A H1N1 emerged
as a problem at the world level due to the neuraminidase (NA) mutations. The NA mutants …
as a problem at the world level due to the neuraminidase (NA) mutations. The NA mutants …