Protein kinase C (PKC) isozymes as diagnostic and prognostic biomarkers and therapeutic targets for cancer

T Kawano, J Inokuchi, M Eto, M Murata, JH Kang - Cancers, 2022 - mdpi.com
Simple Summary Protein kinase C (PKC) isozymes play key roles in the proliferation,
differentiation, survival, migration, invasion, apoptosis, and anticancer drug resistance of …

Krüppel-like factor-9 and Krüppel-like factor-13: highly related, multi-functional, transcriptional repressors and activators of oncogenesis

FA Simmen, I Alhallak, RCM Simmen - Cancers, 2023 - mdpi.com
Simple Summary Krüppel-like Factor-9 (KLF9) and Krüppel-like Factor-13 (KLF13) are
highly related proteins that function as inducers and/or repressors of specific target gene …

Determining KLF14 tertiary structure and diagnostic significance in brain cancer progression

K Zahra, M Shabbir, Y Badshah, JH Trembley… - Scientific Reports, 2022 - nature.com
Expression analysis of new protein targets may play a crucial role in the early detection and
diagnosis of brain tumor progression. The study aimed to investigate the possible relation of …

Cross talk of tumor protein D52 (TPD52) with KLF9, PKCε, and MicroRNA 223 in ovarian cancer

K Khan, S Zafar, Y Badshah, NM Ashraf… - Journal of Ovarian …, 2023 - Springer
Background Gynecologic cancers comprise malignancies in the female reproductive organs.
Ovarian cancer ranks sixth in terms of incidence rates while seventh in terms of mortality …

A novel necroptosis-related gene signature associated with immune landscape for predicting the prognosis of papillary thyroid cancer

Z Wang, P Wu, J Shi, X Ji, L He, W Dong, Z Wang… - Frontiers in …, 2022 - frontiersin.org
Background: Necroptosis, a type of programmed cell death, has been implicated in a variety
of cancer-related biological processes. However, the roles of necroptosis-related genes in …

[HTML][HTML] KLF9 deficiency protects the heart from inflammatory injury triggered by myocardial infarction

Z Chang, H Li - The Korean Journal of Physiology & …, 2023 - synapse.koreamed.org
The excessive inflammatory response induced by myocardial infarction exacerbates heart
injury and leads to the development of heart failure. Recent studies have confirmed the …

Elucidating the role of missense SNP of protein kinase C epsilon in HCV-induced hepatocellular carcinoma

A Rehman, M Shabbir, Y Badshah, K Khan… - BMC cancer, 2023 - Springer
Background The protein kinase C (PKC) family of serine/threonine kinases contains more
than ten isozymes that are involved in multiple signaling pathways, including cell cycle …

[PDF][PDF] Protein Kinase C (PKC) Isozymes as Diagnostic and Prognostic Biomarkers and Therapeutic Targets for Cancer. Cancers 2022, 14, 5425

T Kawano, J Inokuchi, M Eto, M Murata, JH Kang - 2022 - pdfs.semanticscholar.org
Protein kinase C (PKC) is a large family of calcium-and phospholipid-dependent
serine/threonine kinases that consists of at least 11 isozymes. Based on their structural …

Disruption of p54nrb's gene regulatory function by caspase-2 exhibits a multifaceted role in tumor cell death susceptibility

M Eichler - 2023 - publikationen.ub.uni-frankfurt.de
Caspase-2 is the evolutionary most conserved member of the caspase family and was
shown to be involved in genotoxic stress induced apoptosis, control of aneuploidy, and …

[PDF][PDF] A novel necroptosis-related genes signature for predicting the prognosis of thyroid cancer

W Sun, Z Wang, P Wu, J Shi, X Ji, H Zhang - 2022 - scholar.archive.org
Background: Necroptosis, a type of programmed cell death, has been implicated in a variety
of cancerrelated biological processes. However, the roles of necroptosis-related genes in …