Mitochondria in health, disease, and aging

JS Harrington, SW Ryter, M Plataki… - Physiological …, 2023 - journals.physiology.org
Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Non-coding RNAs in disease: from mechanisms to therapeutics

K Nemeth, R Bayraktar, M Ferracin… - Nature Reviews Genetics, 2024 - nature.com
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …

Neutrophil-to-lymphocyte ratio, past, present and future perspectives

R Zahorec - Bratisl Lek Listy, 2021 - search.ebscohost.com
In the review we analyzed short history of the establishment of a novel hematological
parameter for systemic inflammation and stress coined as a neutrophil to lymphocyte ratio …

[HTML][HTML] The multifaceted nature of antimicrobial peptides: Current synthetic chemistry approaches and future directions

BH Gan, J Gaynord, SM Rowe, T Deingruber… - Chemical Society …, 2021 - pubs.rsc.org
Bacterial infections caused by 'superbugs' are increasing globally, and conventional
antibiotics are becoming less effective against these bacteria, such that we risk entering a …

[HTML][HTML] Cytokine storms: understanding COVID-19

N Mangalmurti, CA Hunter - Immunity, 2020 - cell.com
The elevated circulating levels of cytokines associated with a variety of infectious and
immune-mediated conditions are frequently termed a cytokine storm. Here, we explain the …

Ceria‐based therapeutic antioxidants for biomedical applications

YG Kim, Y Lee, N Lee, M Soh, D Kim… - Advanced …, 2024 - Wiley Online Library
The growing interest in nanomedicine over the last 20 years has carved out a research field
called “nanocatalytic therapy,” where catalytic reactions mediated by nanomaterials are …

[HTML][HTML] The systemic inflammation hypothesis: towards a new paradigm of acute decompensation and multiorgan failure in cirrhosis

V Arroyo, P Angeli, R Moreau, R Jalan, J Clària… - Journal of …, 2021 - Elsevier
Acute decompensation (AD) of cirrhosis is defined by the development of ascites, hepatic
encephalopathy (HE) and/or variceal bleeding. Ascites is traditionally attributed to …

[HTML][HTML] Cytokine storm—definition, causes, and implications

D Jarczak, A Nierhaus - International journal of molecular sciences, 2022 - mdpi.com
The human innate and adaptive immune systems consist of effector cells producing
cytokines (interleukins, interferons, chemokines, and numerous other mediators). Usually, a …

[HTML][HTML] Multi-organ proteomic landscape of COVID-19 autopsies

X Nie, L Qian, R Sun, B Huang, X Dong, Q Xiao… - Cell, 2021 - cell.com
The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear,
preventing effective therapeutics development. Here, we report a proteomic analysis of 144 …

Sepsis and Septic Shock–Basics of diagnosis, pathophysiology and clinical decision making

MD Font, B Thyagarajan, AK Khanna - Medical Clinics, 2020 - medical.theclinics.com
As of 2017, the World Health Organization has made the recognition, prevention, and
management of sepsis a global health priority. 1 Hippocrates considered the term a …