[PDF][PDF] Genome-wide risk prediction of common diseases across ancestries in one million people

N Mars, S Kerminen, YCA Feng, M Kanai, K Läll… - Cell Genomics, 2022 - cell.com
Polygenic risk scores (PRS) measure genetic disease susceptibility by combining risk effects
across the genome. For coronary artery disease (CAD), type 2 diabetes (T2D), and breast …

[HTML][HTML] Decoding the genetic relationship between Alzheimer's disease and type 2 diabetes: potential risk variants and future direction for North Africa

W Boukhalfa, H Jmel, N Kheriji, I Gouiza… - Frontiers in Aging …, 2023 - frontiersin.org
Introduction: Alzheimer's disease (AD) and Type 2 diabetes (T2D) are both age-associated
diseases. Identification of shared genes could help develop early diagnosis and preventive …

Generalizability of polygenic risk scores for breast cancer among women with European, African, and Latinx ancestry

C Liu, N Zeinomar, WK Chung, K Kiryluk… - JAMA network …, 2021 - jamanetwork.com
Importance Multiple polygenic risk scores (PRSs) for breast cancer have been developed
from large research consortia; however, their generalizability to diverse clinical settings is …

Incidence of proliferative diabetic retinopathy and other neovascular sequelae at 5 years following diagnosis of type 2 diabetes

WS Gange, J Lopez, BY Xu, K Lung… - Diabetes …, 2021 - Am Diabetes Assoc
OBJECTIVE To determine the incidence and risk factors for developing proliferative diabetic
retinopathy (PDR), tractional retinal detachment (TRD), and neovascular glaucoma (NVG) at …

[PDF][PDF] Type 2 diabetes mellitus in latinx populations in the United States: A culturally relevant literature review

TM Vidal, CA Williams, UD Ramoutar, F Haffizulla - Cureus, 2022 - cureus.com
Type 2 diabetes mellitus (T2DM) affects a large number of the American population. When
compared to their representation in the general American population, a disproportionate …

MUC22, HLA-A, and HLA-DOB variants and COVID-19 in resilient super-agers from Brazil

EC Castelli, MV de Castro, MS Naslavsky… - Frontiers in …, 2022 - frontiersin.org
Background Although aging correlates with a worse prognosis for Covid-19, super elderly
still unvaccinated individuals presenting mild or no symptoms have been reported …

Socioeconomic deprivation and genetic ancestry interact to modify type 2 diabetes ethnic disparities in the United Kingdom

SD Nagar, AM Nápoles, IK Jordan… - …, 2021 - thelancet.com
Abstract Background Type 2 diabetes (T2D) is a complex common disease that
disproportionately impacts minority ethnic groups in the United Kingdom (UK) …

Genetically determined levels of mTOR-dependent circulating proteins and risk of multiple sclerosis

YC Zhang, KY Fan, Q Wang, JX Hu, Q Wang… - Neurology and …, 2023 - Springer
Background Results from observational studies indicate an association between circulating
levels of mammalian target of rapamycin (mTOR)-dependent circulating proteins and the risk …

[HTML][HTML] The impact of ethnicity and genetic ancestry on disease prevalence and risk in Colombia

AT Chande, SD Nagar, L Rishishwar… - Frontiers in …, 2021 - frontiersin.org
Currently, the vast majority of genomic research cohorts are made up of participants with
European ancestry. Genomic medicine will only reach its full potential when genomic …

[HTML][HTML] Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon

IG Diniz, RRD Noce, AP Pereira, ANLM Silva… - … and Molecular Biology, 2022 - SciELO Brasil
This study was carried out to investigate the frequency of genetic variants related to body
mass index (BMI) and type 2 diabetes (T2D) and evaluating the potential impact of risk …