The role of peroxisome proliferator-activated receptors in preeclampsia

I Psilopatis, K Vrettou, FN Fleckenstein, S Theocharis - Cells, 2023 - mdpi.com
Preeclampsia is a common pregnancy-related hypertensive disorder. Often presenting as
preexisting or new-onset hypertension complicated by proteinuria and/or end-organ …

The regulation and potential roles of m6A modifications in early embryonic development and immune tolerance at the maternal-fetal interface

H Liu, J Zheng, A Liao - Frontiers in Immunology, 2022 - frontiersin.org
The immune microenvironment at the maternal-fetal interface was determined by the
crosstalk between the trophoblast and maternal-derived cells, which dynamically changed …

Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner

Y Chen, X Liu, L Li, X He, F Zheng, Y Zhang, H Gao… - Molecular …, 2023 - Springer
Background With the increasing morbidity and mortality of preeclampsia (PE), it has posed a
huge challenge to public health. Previous studies have reported endoplasmic reticulum (ER) …

RNA methylation and cellular response to oxidative stress-promoting anticancer agents

M Ponzetti, N Rucci, S Falone - Cell Cycle, 2023 - Taylor & Francis
Disruption of the complex network that regulates redox homeostasis often underlies resistant
phenotypes, which hinder effective and long-lasting cancer eradication. In addition, the RNA …

RNA N6-methyladenosine modification in female reproductive biology and pathophysiology

E Huang, L Chen - Cell Communication and Signaling, 2023 - Springer
Gene expression and posttranscriptional regulation can be strongly influenced by epigenetic
modifications. N6-methyladenosine, the most extensive RNA modification, has been …

N6‐methyladenosine modification in trophoblasts promotes circSETD2 expression, inhibits miR‐181a‐5p, and elevates MCL1 transcription to reduce apoptosis of …

D Wang, H Guan, Y Wang, G Song… - Environmental …, 2023 - Wiley Online Library
Preeclampsia (PE) is an obstetric disorder. N6‐methyladenosine (m6A) modification is
related to PE trophoblast biological behaviors. This study explored the mechanism of m6A …

The landscape of implantation and placentation: deciphering the function of dynamic RNA methylation at the maternal-fetal interface

S Wu, H Xie, Y Su, X Jia, Y Mi, Y Jia… - Frontiers in …, 2023 - frontiersin.org
The maternal-fetal interface is defined as the interface between maternal tissue and sections
of the fetus in close contact. RNA methylation modifications are the most frequent kind of …

IGF2BP2 enhances LincRNA01116 stability via m6A: A potential biomarker and therapeutic target for patients with pre‐eclampsia

T Zhang, X Tang, Y Zhu, C Wang… - Journal of Cellular …, 2023 - Wiley Online Library
Pre‐eclampsia (PE) is a serious complication in pregnant women characterized by failure of
placental remodeling and is one of the primary causes of changes in the placental structure …

m6A modification mediates endothelial cell responses to oxidative stress in vascular aging induced by low fluid shear stress

Z Xu, P Qiu, Y Jiang, J Hu, Z Wu, J Lei… - Oxidative Medicine …, 2023 - Wiley Online Library
N6‐methyladenosine (m6A) is one of the most prevalent, abundant, and internal
transcriptional modification and plays essential roles in diverse cellular and physiological …

Bioinformatics analysis combined with clinical sample screening reveals that leptin may be a biomarker of preeclampsia

Y Wang, X Bai, X Guo, X Gao, Y Chen, H Li… - Frontiers in …, 2023 - frontiersin.org
Introduction: Preeclampsia (PE) is a gestational hypertensive disease with unclear
pathogenesis. This study aimed to identify the genes that play an important role in …