Signaling pathways and targeted therapy for myocardial infarction

Q Zhang, L Wang, S Wang, H Cheng, L Xu… - Signal transduction and …, 2022 - nature.com
Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

Interplay between inflammation and thrombosis in cardiovascular pathology

K Stark, S Massberg - Nature Reviews Cardiology, 2021 - nature.com
Thrombosis is the most feared complication of cardiovascular diseases and a main cause of
death worldwide, making it a major health-care challenge. Platelets and the coagulation …

Interplay between platelets and coagulation

Y Sang, M Roest, B de Laat, PG de Groot, D Huskens - Blood reviews, 2021 - Elsevier
Haemostasis stops bleeding at the site of vascular injury and maintains the integrity of blood
vessels through clot formation. This regulated physiological process consists of complex …

Thrombus structural composition in cardiovascular disease

G Alkarithi, C Duval, Y Shi, FL Macrae… - … , and vascular biology, 2021 - Am Heart Assoc
Thrombosis is a major complication of cardiovascular disease, leading to myocardial
infarction, acute ischemic stroke, or venous thromboembolism. Thrombosis occurs when a …

Near-infrared-II photoacoustic imaging and photo-triggered synergistic treatment of thrombosis via fibrin-specific homopolymer nanoparticles

J Song, X Kang, L Wang, D Ding, D Kong, W Li… - Nature …, 2023 - nature.com
The formation of an occlusive thrombus in the blood vessel is the main culprit for numerous
life-threatening cardiovascular diseases that represent the leading cause of morbidity and …

Pathophysiological mechanisms of thrombosis in acute and long COVID-19

H Jing, X Wu, M Xiang, L Liu, VA Novakovic… - Frontiers in …, 2022 - frontiersin.org
COVID-19 patients have a high incidence of thrombosis, and thromboembolic complications
are associated with severe COVID-19 and high mortality. COVID-19 disease is associated …

Anticoagulants: a short history, their mechanism of action, pharmacology, and indications

M Heestermans, G Poenou, H Hamzeh-Cognasse… - Cells, 2022 - mdpi.com
Anticoagulant drugs antagonize coagulation and are used to prevent or cure (recurrent)
venous thromboembolism (VTE). Drugs to prevent clotting have been used for more than a …

Factor XI inhibitors: cardiovascular perspectives

R De Caterina, D Prisco… - European Heart …, 2023 - academic.oup.com
Anticoagulants are the cornerstone for prevention and treatment of thrombosis but are not
completely effective, and concerns about the risk of bleeding continue to limit their uptake …

Platelet in thrombo-inflammation: Unraveling new therapeutic targets

S Sharma, T Tyagi, S Antoniak - Frontiers in immunology, 2022 - frontiersin.org
In the broad range of human diseases, thrombo-inflammation appears as a clinical
manifestation. Clinically, it is well characterized in context of superficial thrombophlebitis that …

Dynamic responsiveness of self‐assembling peptide‐based nano‐drug systems

Y Wang, J Zhan, J Huang, X Wang… - Interdisciplinary …, 2023 - Wiley Online Library
Dynamic‐responsive self‐assembly is the process of ordered supramolecular structure
formation or reversible decomposition from building blocks. This process is driven by non …