AAV9-mediated SH3TC2 gene replacement therapy targeted to Schwann cells for the treatment of CMT4C
E Georgiou, A Kagiava, I Sargiannidou, N Schiza… - Molecular Therapy, 2023 - cell.com
Type 4C Charcot-Marie-Tooth (CMT4C) demyelinating neuropathy is caused by autosomal
recessive SH3TC2 gene mutations. SH3TC2 is highly expressed in myelinating Schwann …
recessive SH3TC2 gene mutations. SH3TC2 is highly expressed in myelinating Schwann …
Enhancer cooperativity can compensate for loss of activity over large genomic distances
HF Thomas, S Feng, M Huber, V Loubiere, D Vanina… - bioRxiv, 2023 - biorxiv.org
Enhancers are short DNA sequences that activate their target promoter from a distance;
however, increasing the genomic distance between the enhancer and the promoter …
however, increasing the genomic distance between the enhancer and the promoter …
Natural Killer Cells and Their Implications in Immune Response Diversification in Clinical Pathology and Neoplastic Processes
I Legaz, M Muro - International Journal of Molecular Sciences, 2023 - mdpi.com
Numerous studies have examined the function of human immune system biomarkers
regarding susceptibility, and prognostic, therapeutic, and predictive factors, in various solid …
regarding susceptibility, and prognostic, therapeutic, and predictive factors, in various solid …
[PDF][PDF] Revolutionizing Medicine: Breakthrough Cell-Based Delivery System for Targeted Therapy Unveiled.
R Solofondrazaintsoanirina - 2023 - hcommons.org
The global burden of cancer remains high, with tens of millions of new cases being
diagnosed and millions of lives being lost to the disease each year. Chemotherapy and …
diagnosed and millions of lives being lost to the disease each year. Chemotherapy and …
Tranksripcijos faktoriaus p53 fluorescencinio reporterio sukūrimas, modifikavimas ir pritaikymas
J Černuševič - 2023 - epublications.vu.lt
Abstract [eng] P53 is an extremely important for cancer supression transcription factor. Thus,
it would be beneficial to assess its transcriptional activity in living cells in real time. This can …
it would be beneficial to assess its transcriptional activity in living cells in real time. This can …
[PDF][PDF] MASTERARBEIT/MASTER'S THESIS
JM Franz - 2018 - phaidra.univie.ac.at
Cancer cells exhibit fundamental defects in the regulatory circuits that control normal cell
proliferation and cellular homeostasis (Hanahan, 2022), leading to one of the highest rates …
proliferation and cellular homeostasis (Hanahan, 2022), leading to one of the highest rates …