CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of
substrates, controls several signaling pathways, and is implicated in a plethora of human …

Targeted therapy has emerged to be the cornerstone of advanced cancer treatment,
allowing for more selectivity and avoiding the common drug toxicity and resistance …

Protein kinase CK2 has received a surge of attention in recent years due to the evidence of
its overexpression in a variety of solid tumors and multiple myelomas as well as its …

Casein kinase II (CK2) is an ubiquitous and pleiotropic serine/threonine protein kinase able
to phosphorylate hundreds of substrates. Being implicated in several human diseases, from …

CK2 is a protein kinase that plays important roles in many physio-pathological cellular
processes. As such, the development of chemical probes for CK2 has received increasing …

CK2 is a constitutively active Ser/Thr protein kinase which phosphorylates hundreds of
substrates. Since they are primarily related to survival and proliferation pathways, the best …

Identifying a pharmacological agent that targets only one of more than 500 kinases present
in humans is an important challenge. One potential solution to this problem is the …

Glioblastoma (GBM) causes poor survival in patients even with aggressive treatment.
Temozolomide (TMZ) is the standard chemotherapeutic choice for GBM treatment but …

Protein Kinase CK2, a constitutively active serine/threonine kinase, fulfills its functions via
phosphorylating hundreds of proteins in nearly all cells. It regulates a variety of cellular …

Serine/threonine protein kinases (CK2, PIM-1, RIO1) are constitutively active, highly
conserved, pleiotropic, and multifunctional kinases, which control several signaling …