Cortical spreading depolarization (CSD) is a promising target for neuroprotective therapy in
traumatic brain injury (TBI). We explored the effect of NMDA receptor antagonism on …

Biomarkers such as calcium channel binding protein S100 subunit beta (S100B), glial
fibrillary acidic protein (GFAP), ubiquitin c-terminal hydrolase L1 (UCH-L1) and neuron …

The blood–brain barrier is a highly selective anatomical and functional interface allowing a
unique environment for neuro-glia networks. Blood–brain barrier dysfunction is common in …

Although concussion is now recognized as a major health issue, its non-lethal nature has
limited characterization of the underlying pathophysiology. In particular, potential …

Traumatic brain injury (TBI) is a major global health issue, with outcomes spanning from
intracranial bleeding, debilitating sequelae, and invalidity with consequences for individuals …

Abstract Purpose of Review The concussion public health burden has increased alongside
our knowledge of the pathophysiology of mild traumatic brain injury (mTBI). The purpose of …

Traumatic brain injury (TBI) is one the most common human afflictions, contributing to long-
term disability in survivors. Emerging data indicate that functional improvement or …

Bipolar disorder affects approximately 2% of the population and is typically characterized by
recurrent episodes of mania and depression. While some patients achieve remission using …

Mild traumatic brain injury (mTBI) represents more than 80% of total TBI cases and is a
robust environmental risk factor for neurodegenerative diseases including Alzheimer's …

A biomarker that will enable the identification of patients at high-risk for developing post-
injury epilepsy is critically required. Microvascular pathology and related blood–brain barrier …