[HTML][HTML] Machine learning-enabled cancer diagnostics with widefield polarimetric second-harmonic generation microscopy

K Mirsanaye, L Uribe Castaño, Y Kamaliddin… - Scientific reports, 2022 - nature.com
The extracellular matrix (ECM) collagen undergoes major remodeling during tumorigenesis.
However, alterations to the ECM are not widely considered in cancer diagnostics, due to …

[HTML][HTML] Unsupervised determination of lung tumor margin with widefield polarimetric second-harmonic generation microscopy

K Mirsanaye, L Uribe Castaño, Y Kamaliddin… - Scientific Reports, 2022 - nature.com
The extracellular matrix (ECM) is amongst many tissue components affected by cancer,
however, morphological changes of the ECM are not well-understood and thus, often …

Multimodal label-free ex vivo imaging using a dual-wavelength microscope with axial chromatic aberration compensation

A Filippi, E Dal Sasso, L Iop, A Armani… - Journal of …, 2018 - spiedigitallibrary.org
Label-free microscopy is a very powerful technique that can be applied to study samples
with no need for exogenous fluorescent probes, keeping the main benefits of multiphoton …

Double Stokes Mueller polarimetry of second-harmonic generation in ordered molecular structures

M Samim, S Krouglov, V Barzda - JOSA B, 2015 - opg.optica.org
Second-harmonic generation (SHG) is highly sensitive to the structure of ordered
aggregates, and therefore, the polarization measurement of SHG can help to elucidate the …

Nonlinear stokes-mueller polarimetry

M Samim, S Krouglov, V Barzda - Physical Review A, 2016 - APS
The Stokes-Mueller polarimetry is generalized to include nonlinear optical processes such
as second-and third-harmonic generation, sum-and difference-frequency generations with …

Second harmonic generation double stokes Mueller polarimetric microscopy of myofilaments

L Kontenis, M Samim, A Karunendiran… - Biomedical Optics …, 2016 - opg.optica.org
The experimental implementation of double Stokes Mueller polarimetric microscopy is
presented. This technique enables a model-independent and complete polarimetric …

Modeling and predicting second harmonic generation from protein molecular structure

B Asadipour, E Beaurepaire, X Zhang, A Chessel… - Biophysical …, 2024 - cell.com
Polarization resolved second-harmonic-generation (pSHG) microscopy is increasingly used
for mapping organized arrays of non-centrosymmetric proteins such as collagen, myosin …

Second harmonic generation mediated by aligned water in starch granules

R Cisek, D Tokarz, S Krouglov, M Steup… - The Journal of …, 2014 - ACS Publications
The origin of second harmonic generation (SHG) in starch granules was investigated using
ab initio quantum mechanical modeling and experimentally examined using polarization-in …

Crystal lattice determination of ZnSe nanowires with polarization-dependent second harmonic generation microscopy

R Cisek, D Tokarz, N Hirmiz, A Saxena, A Shik… - …, 2014 - iopscience.iop.org
We demonstrate a noninvasive optical microscopy technique based on polarization-
dependent second harmonic generation for determining the crystal lattice structure and …

Three-photon Stokes-Mueller polarimetry

M Samim, S Krouglov, V Barzda - Physical Review A, 2016 - APS
The generalized theory of Stokes-Mueller polarimetry is employed to develop the third-order
optical polarimetry framework for third-harmonic generation (THG). The outgoing and …