Drug resistance in nontuberculous mycobacteria: mechanisms and models

S Saxena, HP Spaink, G Forn-Cuní - Biology, 2021 - mdpi.com
Simple Summary Recently, there has been a considerable rise in infections caused by
nontuberculous mycobacteria (NTM). These mycobacteria, which comprise a large and …

Does Mycobacterium tuberculosis var. bovis Survival in the Environment Confound Bovine Tuberculosis Control and Eradication? A Literature Review

AR Allen, T Ford, RA Skuce - Veterinary medicine international, 2021 - Wiley Online Library
Bovine tuberculosis (bTB) is one of the globe's most common, multihost zoonoses and
results in substantial socioeconomic costs for governments, farming industries, and tax …

Mycobacteria–host interactions in human bronchiolar airway organoids

N Iakobachvili, SA Leon‐Icaza, K Knoops… - Molecular …, 2022 - Wiley Online Library
Respiratory infections remain a major global health concern. Tuberculosis is one of the top
10 causes of death worldwide, while infections with Non‐Tuberculous Mycobacteria are …

Phage therapy for nontuberculous mycobacteria: challenges and opportunities

GF Hatfull - Pulmonary Therapy, 2023 - Springer
Non-tuberculous mycobacterium (NTM) infections are often clinically challenging, with
lengthy antibiotic regimens that fail to resolve the infections with few good outcomes …

Current and Emerging Inhaled Antibiotics for Chronic Pulmonary Pseudomonas aeruginosa and Staphylococcus aureus Infections in Cystic Fibrosis

D Li, EK Schneider-Futschik - Antibiotics, 2023 - mdpi.com
Characterized by impaired mucus transport and subsequent enhanced colonization of
bacteria, pulmonary infection causes major morbidity and mortality in patients with cystic …

[HTML][HTML] Bioengineered Co-culture of organoids to recapitulate host-microbe interactions

MB Kim, S Hwangbo, S Jang, YK Jo - Materials Today Bio, 2022 - Elsevier
The recent spike in the instances of complex physiological host-microbe interactions has
raised the demand for developing in vitro models that recapitulate the microbial …

3D human organoids: the next “viral” model for the molecular basis of infectious diseases

SPS Chia, SLY Kong, JKS Pang, BS Soh - Biomedicines, 2022 - mdpi.com
The COVID-19 pandemic has driven the scientific community to adopt an efficient and
reliable model that could keep up with the infectious disease arms race. Coinciding with the …

A leucyl-tRNA synthetase inhibitor with broad-spectrum antimycobacterial activity

US Ganapathy, R González del Rio… - Antimicrobial agents …, 2021 - Am Soc Microbiol
Global infections by nontuberculous mycobacteria (NTM) are steadily rising. New drugs are
needed to treat NTM infections, but the NTM drug pipeline remains poorly populated and …

Colloidal silver against macrophage infections and biofilms of atypical mycobacteria

S Feizi, CM Cooksley, M Ramezanpour, R Nepal… - Biometals, 2023 - Springer
Skin and soft tissue infection (SSTI) caused by atypical mycobacteria such as
Mycobacterium abscessus and Mycobacterium avium intracellulare complex (MAIC) have …

Synthesis and Characterization of Phenylalanine Amides Active against Mycobacterium abscessus and Other Mycobacteria

M Lang, US Ganapathy, L Mann… - Journal of medicinal …, 2023 - ACS Publications
N α-2-thiophenoyl-d-phenylalanine-2-morpholinoanilide [MMV688845, Pathogen Box;
Medicines for Malaria Venture; IUPAC:(2 R)-N-(1-((2-morpholinophenyl) amino)-1-oxo-3 …