[HTML][HTML] Analysis of the management and therapeutic performance of diabetes mellitus employing special target
HY Sun, XY Lin - World Journal of Diabetes, 2023 - ncbi.nlm.nih.gov
Diabetes mellitus (DM) is a chronic metabolic condition characterized predominantly by
hyperglycemia. The most common causes contributing to the pathophysiology of diabetes …
hyperglycemia. The most common causes contributing to the pathophysiology of diabetes …
Brain uptake pharmacokinetics of albiglutide, dulaglutide, tirzepatide, and DA5-CH in the search for new treatments of Alzheimer's and Parkinson's diseases
EM Rhea, A Babin, P Thomas, M Omer, R Weaver… - Tissue …, 2023 - Taylor & Francis
Background A number of peptide incretin receptor agonists (IRAs) show promise as
therapeutics for Alzheimer's disease (AD) and Parkinson's disease (PD). Transport across …
therapeutics for Alzheimer's disease (AD) and Parkinson's disease (PD). Transport across …
[HTML][HTML] The foot in diabetes–a reminder of an ever-present risk
S Craus, A Mula, DV Coppini - Clinical Medicine, 2023 - Elsevier
The term 'diabetic foot disease'(DFD) often signifies the presence of foot ulceration and
infection, but one must also be wary of the rarer occurrence of Charcot foot disease. The …
infection, but one must also be wary of the rarer occurrence of Charcot foot disease. The …
Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with Gs proteins
Z Cong, F Zhao, Y Li, G Luo, Y Mai, X Chen, Y Chen… - Cell Discovery, 2024 - nature.com
Class B1 G protein-coupled receptors (GPCRs) are important regulators of many
physiological functions such as glucose homeostasis, which is mainly mediated by three …
physiological functions such as glucose homeostasis, which is mainly mediated by three …
Binding sites and design strategies for small molecule GLP-1R Agonists
H Zhang, T Wu, Y Wu, Y Peng, X Wei, T Lu… - European Journal of …, 2024 - Elsevier
Abstract Glucagon-like peptide-1 receptor (GLP-1R) is a pivotal receptor involved in blood
glucose regulation and influencing feeding behavior. It has received significant attention in …
glucose regulation and influencing feeding behavior. It has received significant attention in …
Regulation of Human Sortilin Alternative Splicing by Glucagon-like Peptide-1 (GLP1) in Adipocytes
Type 2 diabetes mellitus is a chronic metabolic disease with no cure. Adipose tissue is a
major site of systemic insulin resistance. Sortilin is a central component of the glucose …
major site of systemic insulin resistance. Sortilin is a central component of the glucose …
The role of nanosystems in the delivery of glucose-lowering drugs for the preemption and treatment of diabetes-associated atherosclerosis
LJ Conroy, A McCann, N Zhang… - American Journal of …, 2024 - journals.physiology.org
Diabetes is one of the most prevalent diseases worldwide. In recent decades, type-2
diabetes has become increasingly common, particularly in younger individuals. Diabetes …
diabetes has become increasingly common, particularly in younger individuals. Diabetes …
Cryo-electron microscopy-based drug design
E Cebi, J Lee, VK Subramani, N Bak, C Oh… - Frontiers in Molecular …, 2024 - frontiersin.org
Structure-based drug design (SBDD) has gained popularity owing to its ability to develop
more potent drugs compared to conventional drug-discovery methods. The success of …
more potent drugs compared to conventional drug-discovery methods. The success of …
Effects of liraglutide on ANP secretion and cardiac dynamics
S Luo, Y Zuo, X Cui, M Zhang, H Jin… - Endocrine …, 2023 - ec.bioscientifica.com
To observe the effects of liraglutide (analog of glucagon-like peptide 1 (GLP-1)) on atrial
natriuretic peptide (ANP) secretion and atrial dynamics, an ex vivo isolated rat atrial …
natriuretic peptide (ANP) secretion and atrial dynamics, an ex vivo isolated rat atrial …
Polymorphisms in the glucagon-like peptide-1 receptor gene and their interactions on the risk of osteoporosis in postmenopausal Chinese women
C Liu, X Bao, Y Tian, P Xue, Y Wang, Y Li - Plos one, 2023 - journals.plos.org
Postmenopausal osteoporosis (PMOP) is a prevalent form of primary osteoporosis, affecting
over 40% of postmenopausal women. Previous studies have suggested a potential …
over 40% of postmenopausal women. Previous studies have suggested a potential …