Advanced prostate cancers comprise distinct phenotypes, but tumor classification remains
clinically challenging. Here, we harnessed circulating tumor DNA (ctDNA) to study tumor …

Determining chromatin-associated protein localization across the genome has provided
insight into the functions of DNA-binding proteins and their connections to disease …

Proteins and enzymes in the cell nucleus require physical access to their DNA target sites in
order to perform genomic tasks such as gene activation and transcription. Hence, chromatin …

Abstract The Human Genome Project marked a major milestone in the scientific community
as it unravelled the~ 3 billion bases that are central to crucial aspects of human life. Despite …

Chromatin organization and transcriptional profiles undergo tremendous reordering during
senescence. However, uncovering the regulatory mechanisms between chromatin …

The contact inhibition of proliferation (CIP) denotes the cell density-dependent inhibition of
growth, and the loss of CIP represents a hallmark of cancer. However, the mechanism by …

The most fundamental region of the chromosome for maintaining accurate genome
segregation and stability is the centromeric chromatin [1, 2]. In this review, we will focus on …

Crop wild relatives (CWRs) are recognized as the best potential source of traits for crop
improvement. However, successful crop improvement using CWR relies on identifying …

Elucidating the mechanisms underlying chromatin maintenance upon genome replication is
critical for the understanding of how gene expression programs and cell identity are …

Our understanding of the mechanisms that modulate gene expression in animals is strongly
biased by studying a handful of model species that mainly belong to three groups: Insecta …