The diverse variety of diseases creates a threat to human lives, which increases the mortality
rate. The antibiotics are practiced in the medical profession to find an antidote for these …

核小体是染色质复杂三维结构的基本单位, 它在基因组上的定位及占位在DNA 转录,
复制和修复等基础生物过程中发挥重要功能. 在众多核小体定占位研究技术中 …

Neurodevelopment is a complex and finely orchestrated process, deficiencies in which have
major effects on lifelong health outcomes. The epigenetic machinery is a key modulator of …

Nucleosomes are non-uniformly distributed across eukarytic genomes, with stretches of
'open'chromatin strongly associated with transcriptionally active promoters and enhancers …

Summary Cleavage Under Targets & Tagmentation (CUT&Tag) is an antibody-directed
transposase tethering strategy for in situ chromatin profiling in small samples and single …

Different omics techniques allow us to characterize the genetic, transcriptomic, epigenomic,
and proteomic landscapes of cells and tissues and better understand their perturbations in …

Als zirkulierende freie DNA (cfDNA) wird im Blutplasma oder anderen Körperflüssigkeiten
außerhalb von Zellen vorkommendende DNA bezeichnet. Diese wird vorherrschend im …

Genome-wide accessible chromatin sequencing and identification has enabled deciphering
the epigenetic information encoded in chromatin, revealing accessible promoters …

No systematic method exists to derive intra-chromosomal potentials between nucleosomes
along a chromosome consistently across a given genome. Such potentials can yield …

A central concern in genetics is to identify mechanisms of transcriptional regulation. The aim
is to unravel the mapping between the DNA sequence and gene expression. However, it …