5-fluorouracil and other fluoropyrimidines in colorectal cancer: Past, present and future
S Vodenkova, T Buchler, K Cervena… - Pharmacology & …, 2020 - Elsevier
Fluorouracil (5-FU) is an essential component of systemic chemotherapy for colorectal
cancer (CRC) in the palliative and adjuvant settings. Over the past four decades, several …
cancer (CRC) in the palliative and adjuvant settings. Over the past four decades, several …
Long non-coding RNAs: the regulatory mechanisms, research strategies, and future directions in cancers
N Gao, Y Li, J Li, Z Gao, Z Yang, Y Li, H Liu… - Frontiers in …, 2020 - frontiersin.org
The development and application of whole genome sequencing technology has greatly
broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs …
broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs …
The long noncoding RNA Malat1: Its physiological and pathophysiological functions
Recent studies suggest that in humans, DNA sequences responsible for protein coding
regions comprise only 2% of the total genome. The rest of the transcripts result in RNA …
regions comprise only 2% of the total genome. The rest of the transcripts result in RNA …
LncRNA HOXA11-AS promotes proliferation and invasion of gastric cancer by scaffolding the chromatin modification factors PRC2, LSD1, and DNMT1
Long noncoding RNAs (lncRNA) have been implicated in human cancer but their
mechanisms of action are mainly undocumented. In this study, we investigated lncRNA …
mechanisms of action are mainly undocumented. In this study, we investigated lncRNA …
LncRNA LINC00969 promotes acquired gefitinib resistance by epigenetically suppressing of NLRP3 at transcriptional and posttranscriptional levels to inhibit …
J Dai, T Qu, D Yin, Y Cui, C Zhang, E Zhang… - Cell death & …, 2023 - nature.com
Epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) treatment prolongs
the survival of lung cancer patients harbouring activating EGFR mutations. However …
the survival of lung cancer patients harbouring activating EGFR mutations. However …
Non-coding RNAs: the new central dogma of cancer biology
The central dogma of molecular biology states that the functions of RNA revolve around
protein translation. Until the last decade, most researches were geared towards …
protein translation. Until the last decade, most researches were geared towards …
The growth arrest-specific transcript 5 (GAS5): a pivotal tumor suppressor long noncoding RNA in human cancers
C Ma, X Shi, Q Zhu, Q Li, Y Liu, Y Yao, Y Song - Tumor Biology, 2016 - Springer
Long noncoding RNAs (lncRNAs), which refer to a group of RNAs with length more than 200
nucleotides and limited protein-coding potential, play a widespread role in regulating …
nucleotides and limited protein-coding potential, play a widespread role in regulating …
The lncRNA MALAT1 contributes to non‐small cell lung cancer development via modulating miR‐124/STAT3 axis
S Li, Z Mei, HB Hu, X Zhang - Journal of Cellular Physiology, 2018 - Wiley Online Library
lncRNAs can exert many biological effects in several cancer types. MALAT1 is a kind of
lncRNA which is greatly overexpressed in several tumors including non‐small cell lung …
lncRNA which is greatly overexpressed in several tumors including non‐small cell lung …
Upregulated long non-coding RNA AGAP2-AS1 represses LATS2 and KLF2 expression through interacting with EZH2 and LSD1 in non-small-cell lung cancer cells
Recently, long non-coding RNAs (lncRNAs) are identified as new crucial regulators of
diverse cellular processes, including cell proliferation, differentiation and cancer cells …
diverse cellular processes, including cell proliferation, differentiation and cancer cells …