Oxidative stress and antioxidant defense

E Birben, UM Sahiner, C Sackesen, S Erzurum… - World allergy …, 2012 - Springer
Reactive oxygen species (ROS) are produced by living organisms as a result of normal
cellular metabolism and environmental factors, such as air pollutants or cigarette smoke …

Cancer‐associated, stimuli‐driven, turn on theranostics for multimodality imaging and therapy

X Li, J Kim, J Yoon, X Chen - Advanced Materials, 2017 - Wiley Online Library
Advances in bioinformatics, genomics, proteomics, and metabolomics have facilitated the
development of novel anticancer agents that have decreased side effects and increased …

Role of metabolic H2O2 generation: redox signaling and oxidative stress

H Sies - Journal of Biological Chemistry, 2014 - ASBMB
Hydrogen peroxide, the nonradical 2-electron reduction product of oxygen, is a normal
aerobic metabolite occurring at about 10 nm intracellular concentration. In liver, it is …

Antioxidants and human diseases

P Rajendran, N Nandakumar, T Rengarajan… - Clinica chimica acta, 2014 - Elsevier
Oxidative stress plays a pivotal role in the development of human diseases. Reactive
oxygen species (ROS) that includes hydrogen peroxide, hyphochlorus acid, superoxide …

ACTL6A protects gastric cancer cells against ferroptosis through induction of glutathione synthesis

Z Yang, S Zou, Y Zhang, J Zhang, P Zhang… - Nature …, 2023 - nature.com
Gastric cancer (GC), one of the most common malignant tumors in the world, exhibits a rapid
metastasis rate and causes high mortality. Diagnostic markers and potential therapeutic …

The chemistry and biological activities of N-acetylcysteine

Y Samuni, S Goldstein, OM Dean, M Berk - Biochimica et Biophysica Acta …, 2013 - Elsevier
BACKGROUND: N-acetylcysteine (NAC) has been in clinical practice for several decades. It
has been used as a mucolytic agent and for the treatment of numerous disorders including …

The reactive species interactome: evolutionary emergence, biological significance, and opportunities for redox metabolomics and personalized medicine

MM Cortese-Krott, A Koning, GGC Kuhnle… - Antioxidants & redox …, 2017 - liebertpub.com
Significance: Oxidative stress is thought to account for aberrant redox homeostasis and
contribute to aging and disease. However, more often than not, administration of …

[图书][B] Amino acids: biochemistry and nutrition

G Wu - 2021 - taylorfrancis.com
Following its predecessor, the second edition of Amino Acids: Biochemistry and Nutrition
presents exhaustive coverage of amino acids in the nutrition, metabolism and health of …

Glutathione homeostasis and functions: potential targets for medical interventions

VI Lushchak - Journal of amino acids, 2012 - Wiley Online Library
Glutathione (GSH) is a tripeptide, which has many biological roles including protection
against reactive oxygen and nitrogen species. The primary goal of this paper is to …

Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases

S Shadfar, S Parakh, MS Jamali, JD Atkin - Translational …, 2023 - Springer
Redox homeostasis refers to the balance between the production of reactive oxygen species
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …