Carbonic anhydrases in metazoan model organisms: molecules, mechanisms, and physiology
During the past three decades, mice, zebrafish, fruit flies, and Caenorhabditis elegans have
been the primary model organisms used for the study of various biological phenomena …
been the primary model organisms used for the study of various biological phenomena …
Kidney stone disease
FL Coe, A Evan, E Worcester - The Journal of clinical …, 2005 - Am Soc Clin Investig
About 5% of American women and 12% of men will develop a kidney stone at some time in
their life, and prevalence has been rising in both sexes. Approximately 80% of stones are …
their life, and prevalence has been rising in both sexes. Approximately 80% of stones are …
The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters
MD Parker, WF Boron - Physiological reviews, 2013 - journals.physiology.org
The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …
Recombinant protein expression: challenges in production and folding related matters
Protein folding is a biophysical process by which proteins reach a specific three-dimensional
structure. The amino acid sequence of a polypeptide chain contains all the information …
structure. The amino acid sequence of a polypeptide chain contains all the information …
Carbonic anhydrase activators
CT Supuran - Future medicinal chemistry, 2018 - Taylor & Francis
Mammalian carbonic anhydrases (CAs; EC 4.2. 1.1) of which 16 isoforms are known, are
involved in important physiological functions. Their inhibition is exploited pharmacologically …
involved in important physiological functions. Their inhibition is exploited pharmacologically …
Antioxidant activity, acetylcholinesterase, and carbonic anhydrase inhibitory properties of novel ureas derived from phenethylamines
A series of ureas derived from phenethylamines were synthesized and evaluated for human
carbonic anhydrase (hCA) I and II, acetylcholinesterase (AChE), and butyrylcholinesterase …
carbonic anhydrase (hCA) I and II, acetylcholinesterase (AChE), and butyrylcholinesterase …
Proximal renal tubular acidosis: a not so rare disorder of multiple etiologies
SK Haque, G Ariceta, D Batlle - Nephrology Dialysis …, 2012 - academic.oup.com
Proximal renal tubular acidosis (RTA)(Type II RTA) is characterized by a defect in the ability
to reabsorb HCO3 in the proximal tubule. This is usually manifested as bicarbonate wastage …
to reabsorb HCO3 in the proximal tubule. This is usually manifested as bicarbonate wastage …
Genetic causes and mechanisms of distal renal tubular acidosis
D Batlle, SK Haque - Nephrology Dialysis Transplantation, 2012 - academic.oup.com
The primary or hereditary forms of distal renal tubular acidosis (dRTA) have received
increased attention because of advances in the understanding of the molecular mechanism …
increased attention because of advances in the understanding of the molecular mechanism …
Genetics of osteopetrosis
E Palagano, C Menale, C Sobacchi, A Villa - Current osteoporosis reports, 2018 - Springer
Abstract Purpose of Review The term osteopetrosis refers to a group of rare skeletal
diseases sharing the hallmark of a generalized increase in bone density owing to a defect in …
diseases sharing the hallmark of a generalized increase in bone density owing to a defect in …
A clinical and molecular overview of the human osteopetroses
W Balemans, L Van Wesenbeeck… - Calcified tissue …, 2005 - Springer
The osteopetroses are a heterogeneous group of bone remodeling disorders characterized
by an increase in bone density due to a defect in osteoclastic bone resorption. In humans …
by an increase in bone density due to a defect in osteoclastic bone resorption. In humans …