Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

The pursuit to discover the fundamental biology and mechanisms of aging within the context
of the physical and social environment is critical to designing interventions to prevent and …

Cellular senescence is a process that leads to a state of irreversible cell growth arrest
induced by a variety of intrinsic and extrinsic stresses. Senescent cells (SnCs) accumulate …

Aging is an important risk factor for several human diseases such as cancer, cardiovascular
disease and neurodegenerative disorders, resulting from a combination of genetic and …

The sirtuin system consists of seven highly conserved regulatory enzymes responsible for
metabolism, antioxidant protection, and cell cycle regulation. The great interest in sirtuins is …

Decline in biological resilience (ability to recover) is a key manifestation of aging that
contributes to increase in vulnerability to death with age eventually limiting longevity even in …

Inflammaging is a term used to describe the tight relationship between low-grade chronic
inflammation and aging that occurs during physiological aging in the absence of evident …

Life expectancy has increased substantially over the last 150 years. Yet this means that now
most people also spend a greater length of time suffering from various age-associated …

The older population is increasing worldwide, and life expectancy is continuously rising,
predominantly thanks to medical and technological progress. Healthspan refers to the …

Non-obstructive azoospermia (NOA) is a serious cause of male infertility. The Sertoli cell
responds to androgens and takes on roles supporting spermatogenesis, which may cause …