Abstract Background Mesenchymal stromal cells (MSCs) have attracted intense interest due
to their powerful intrinsic properties of self-regeneration, immunomodulation and multi …

Cellular immortality happens upon impairment of cell‐cycle checkpoint pathways
(p53/p16/pRb), reactivation or up‐regulation of telomerase enzyme, or upregulation of some …

In this study, we examined the capacity of a biomimetic pullulan–collagen hydrogel to create
a functional biomaterial-based stem cell niche for the delivery of mesenchymal stem cells …

The roles of Oct4 and Nanog in maintaining self-renewal and undifferentiated status of adult
stem cells are unclear. Here, increase in Oct4 and Nanog expression along with increased …

Although low-density culture provides an efficient method for rapid expansion of human
mesenchymal stem cells (MSCs), MSCs enriched by this method undergo senescence and …

Mesenchymal stem cells (MSC) have attracted considerable attention in the fields of cell and
gene therapy due to their intrinsic ability to differentiate into multiple lineages. The various …

Osteointegration of titanium implants in bone defects is clinically important for long-term
performance of orthopaedic implants. In this work, we developed a facile and effective “one …

The use of patient-derived primary cell cultures in cancer preclinical assays has increased in
recent years. The management of resected tumor tissue remains complex and a number of …

Bone marrow-derived mesenchymal stem/stromal cells (MSCs) have demonstrated success
in the clinical treatment of hematopoietic pathologies and cardiovascular disease and are …

Mesenchymal stem cells (MSC s) hold profound promise in tissue repair/regeneration.
However, MSC s undergo remarkable spontaneous differentiation and aging during …