The development of prophylatic or therapeutic medicines for infectious diseases is one of
the priorities for health organizations worldwide. Innovative solutions are required to achieve …

Advances in reading, writing, and editing DNA are providing unprecedented insights into the
complexity of immunological systems. This combination of systems and synthetic biology …

B cells and their progeny are the sources of highly expressed antibodies. Their high protein
expression capabilities together with their abundance, easy accessibility via peripheral …

The immunoglobulin locus of B cells can be reprogrammed by genome editing to produce
custom or non-natural antibodies that are not induced by immunization. However, current …

The study of Ag-specific lymphocytes has been a key advancement in immunology over the
past few decades. The development of multimerized probes containing Ags, peptide: MHC …

CRISPR-edited murine B cells engineered to express human antibody variable chains
proliferate, class switch, and secrete these antibodies in vaccinated mice. However, current …

T cell-based therapies have been widely explored for the treatment of cancer and chronic
infection, but B cell-based therapies have remained largely unexplored. To study the effect …

Monoclonal antibody-based therapeutics have achieved remarkable success in treating a
wide range of human diseases. However, conventional systemic delivery methods have …

With the number of cases crossing six million (and more than three hundred and seventy
thousand deaths) worldwide, there is a dire need of a vaccine (and repurposing of drugs) for …

Although the development of gene delivery systems based on non-viral vectors is
advancing, it remains a challenge to deliver plasmid DNA into human blood cells. The …