B cells can differentiate into plasmablast and plasma cells, capable of producing antibodies
for decades. Gene editing using zinc-finger nucleases (ZFN) enables the engineering of B …

B cell hyperactivities are involved in the development of systemic lupus erythematosus
(SLE). Toll-like receptor 7 (TLR7) in the B cells plays a pivotal role in the pathogenesis of …

Recent developments in genome editing and delivery systems have opened new
possibilities for B cell gene therapy. CRISPR-Cas9 nucleases have been used to introduce …

B cells have long been an underutilized target in immune cell engineering, despite a
number of unique attributes that could address longstanding challenges in medicine …

Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated enzyme-
CAS holds great promise for treating many uncured human diseases and illnesses by …

Here, we report a novel experimental setup to perform adoptive transfer of gene-edited B
cells using humanized immune system mice by infusing autologous HIS mouse-derived …

Since the early days of vaccination, targeted immunotherapy has gone through multiple
conceptual changes and challenges. It now provides the most efficient and up-to-date …

Human B lymphocytes are attractive targets for immunotherapies in autoantibody-mediated
diseases. Gene editing technologies could provide a powerful tool to determine gene …

Cell therapies based on reprogrammed adaptive immune cells have great potential as"
living drugs." As first demonstrated clinically for engineered chimeric antigen receptor (CAR) …

HIV poses a significant threat to human health. Although some progress has been made in
the development of an HIV vaccine, there is currently no reported success in achieving an …