The study of antigen-specific lymphocytes has been a key advancement in immunology over
the past few decades. One innovation allowing for this type of research was the …

A small number of HIV-1 infected individuals develop broadly neutralizing-antibodies to the
virus (bNAbs). These antibodies are protective against infection in animal models. However …

The high-throughput analysis of antibody responses with regards to their genotypic and
phenotypic features not only provides detailed insights into their basic biology, but can also …

Generating protective antibodies is essential for durable immunity. However, for highly
mutable viruses such as HIV and influenza, conventional vaccination strategies have failed …

Protective neutralizing antibodies against chronic viral pathogens arise late after the onset of
the infection and are not trivial to elicit with immunization. Both in the polyclonal B cell …

Over 38 million people worldwide live with HIV and while antiretroviral therapy (ART)
decreases viral load, increases lifespan, and reduces regression to acquired …

CRISPR–Cas12a was used to directly replace mouse antibody variable chain genes with
human versions in primary B cells. The edited cells underwent affinity maturation in vivo …

HIV broadly neutralizing antibodies (bnAbs) can suppress viremia and protect against 25
infection1. However, their elicitation is made difficult by low frequencies of appropriate 26 …

Les anticorps (ou immunoglobulines, Ig) produits par les lymphocytes B sont essentiels aux
réponses immunitaires induites par les infections et les vaccins. Les anticorps sont des …

Synthetic biology is rapidly contributing to the field of therapeutic development to create
increasingly potent agents for the treatment of a variety of diseases. These living “designer …