Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has become a global crisis
and is more devastating than any other previous infectious disease. It has affected a …

Studies have shown that SARS-CoV-2 has the ability to activate and mature proinflammatory
cytokines in the body. Cytokine markers are a group of polypeptide signalling molecules that …

Abstract Objectives One-fifth of Covid-19 patients suffer a severe course of Covid-19
infection; however, the specific causes remain unclear. Mast cells (MCs) are activated by …

Background Inflammatory responses play a multiphase role in the pathogenesis of cerebral
ischemic stroke (IS). Ruxolitinib (Rux), a selective oral JAK 1/2 inhibitor, reduces …

Emergence of SARS-CoV-2 causing COVID-19 has resulted in hundreds of thousands of
deaths. In search for key targets of effective therapeutics, robust animal models mimicking …

The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

Molecular knowledge of biological processes is a cornerstone in omics data analysis.
Applied to single‐cell data, such analyses provide mechanistic insights into individual cells …

The COVID-19 pandemic has caused a global health crisis, with no specific antiviral to treat
the infection and the absence of a suitable vaccine to prevent it. While some individuals …

The nitrile group is an important functional group widely found in both pharmaceutical
agents and natural products. More than 30 nitrile-containing pharmaceuticals have been …

Host excessive inflammatory immune response to SARS-CoV-2 infection is thought to
underpin the pathogenesis of COVID-19 associated severe pneumonitis and acute lung …