Defining the interorgan communication network: systemic coordination of organismal cellular processes under homeostasis and localized stress
IA Droujinine, N Perrimon - Frontiers in cellular and infection …, 2013 - frontiersin.org
Following the acquisition of multicellularity, organisms with increasing levels of specialized
cells, tissues, and organs emerged during evolution. To coordinate specialized organs, long …
cells, tissues, and organs emerged during evolution. To coordinate specialized organs, long …
Epigenetic memory in response to environmental stressors
Exposure to environmental stressors, toxicants, and nutrient deficiencies can affect DNA in
several ways. Some exposures cause damage and alter the structure of DNA, but there is …
several ways. Some exposures cause damage and alter the structure of DNA, but there is …
Organism-level analysis of vaccination reveals networks of protection across tissues
A fundamental challenge in immunology is to decipher the principles governing immune
responses at the whole-organism scale. Here, using a comparative infection model, we …
responses at the whole-organism scale. Here, using a comparative infection model, we …
Deciphering the effects of gene deletion on yeast longevity using network and machine learning approaches
Longevity is one of the most basic and one of the most essential properties of all living
organisms. Identification of genes that regulate longevity would increase understanding of …
organisms. Identification of genes that regulate longevity would increase understanding of …
Signal propagation in protein interaction network during colorectal cancer progression
Colorectal cancer is generally categorized into the following four stages according to its
development or serious degree: Dukes A, B, C, and D. Since different stage of colorectal …
development or serious degree: Dukes A, B, C, and D. Since different stage of colorectal …
Omics for prediction of environmental health effects: Blood leukocyte-based cross-omic profiling reliably predicts diseases associated with tobacco smoking
The utility of blood-based omic profiles for linking environmental exposures to their potential
health effects was evaluated in 649 individuals, drawn from the general population, in …
health effects was evaluated in 649 individuals, drawn from the general population, in …
[HTML][HTML] Aging on a different scale–chronological versus pathology-related aging
JPM Melis, MJ Jonker, J Vijg, JHJ Hoeijmakers… - Aging (Albany …, 2013 - ncbi.nlm.nih.gov
In the next decades the elderly population will increase dramatically, demanding
appropriate solutions in health care and aging research focusing on healthy aging to …
appropriate solutions in health care and aging research focusing on healthy aging to …
[HTML][HTML] Early cardiac aging linked to impaired stress-resistance and transcriptional control of stress response, quality control and mitochondrial pathways
KJ Ashton, JLM Thompson, AY Aziz, WG Thomas… - Experimental …, 2023 - Elsevier
Phenotypic and transcriptomic evidence of early cardiac aging, and associated
mechanisms, were investigated in young to middle-aged male mice (C57Bl/6; ages 8, 16 …
mechanisms, were investigated in young to middle-aged male mice (C57Bl/6; ages 8, 16 …
A sequence-based approach for predicting protein disordered regions
Protein disordered regions are associated with some critical cellular functions such as
transcriptional regulation, translation and cellular signal transduction, and they are …
transcriptional regulation, translation and cellular signal transduction, and they are …
Dysfunctions associated with methylation, microRNA expression and gene expression in lung cancer
Integrating high-throughput data obtained from different molecular levels is essential for
understanding the mechanisms of complex diseases such as cancer. In this study, we …
understanding the mechanisms of complex diseases such as cancer. In this study, we …