Indole chloropyridinyl ester-derived SARS-CoV-2 3CLpro inhibitors: enzyme inhibition, antiviral efficacy, structure–activity relationship, and X-ray structural studies
AK Ghosh, J Raghavaiah, D Shahabi… - Journal of medicinal …, 2021 - ACS Publications
Here, we report the synthesis, structure–activity relationship studies, enzyme inhibition,
antiviral activity, and X-ray crystallographic studies of 5-chloropyridinyl indole carboxylate …
antiviral activity, and X-ray crystallographic studies of 5-chloropyridinyl indole carboxylate …
[HTML][HTML] COVID-19 vaccines adverse events: potential molecular mechanisms
M Lamprinou, A Sachinidis, E Stamoula, T Vavilis… - Immunologic …, 2023 - Springer
COVID-19 is an infectious disease caused by a single-stranded RNA (ssRNA) virus, known
as SARS-CoV-2. The disease, since its first outbreak in Wuhan, China, in December 2019 …
as SARS-CoV-2. The disease, since its first outbreak in Wuhan, China, in December 2019 …
[HTML][HTML] Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential
B Meyer, J Chiaravalli, S Gellenoncourt… - Nature …, 2021 - nature.com
SARS-CoV-2 is the causative agent behind the COVID-19 pandemic, responsible for over
170 million infections, and over 3.7 million deaths worldwide. Efforts to test, treat and …
170 million infections, and over 3.7 million deaths worldwide. Efforts to test, treat and …
[HTML][HTML] COVID-19 vaccine brand hesitancy and other challenges to vaccination in the Philippines
AML Amit, VCF Pepito… - PLOS Global Public …, 2022 - journals.plos.org
Effective and safe COVID-19 vaccines have been developed at a rapid and unprecedented
pace to control the spread of the virus, and prevent hospitalisations and deaths. However …
pace to control the spread of the virus, and prevent hospitalisations and deaths. However …
Effectiveness of inactivated COVID-19 vaccines against illness caused by the B. 1.617. 2 (Delta) variant during an outbreak in Guangdong, China: a cohort study
M Kang, Y Yi, Y Li, L Sun, A Deng, T Hu… - Annals of internal …, 2022 - acpjournals.org
Background: Real-world evidence on inactivated COVID-19 vaccines against the highly
transmissible B. 1.617. 2 (Delta) variant of SARS-CoV-2 is limited, leaving an important gap …
transmissible B. 1.617. 2 (Delta) variant of SARS-CoV-2 is limited, leaving an important gap …
SARS-CoV-2 nucleocapsid protein adheres to replication organelles before viral assembly at the Golgi/ERGIC and lysosome-mediated egress
KM Scherer, L Mascheroni, GW Carnell… - Science …, 2022 - science.org
Despite being the target of extensive research efforts due to the COVID-19 (coronavirus
disease 2019) pandemic, relatively little is known about the dynamics of severe acute …
disease 2019) pandemic, relatively little is known about the dynamics of severe acute …
[HTML][HTML] A summary of the SARS-CoV-2 vaccines and technologies available or under development
ZA Abdulla, SM Al-Bashir, NS Al-Salih, AA Aldamen… - Pathogens, 2021 - mdpi.com
Since the beginning of 2020, the world has been in a race to develop vaccines that can
control the COVID-19 pandemic. More than 250 projects have been initiated for this …
control the COVID-19 pandemic. More than 250 projects have been initiated for this …
[HTML][HTML] Anti-SARS-CoV-2 receptor-binding domain total antibodies response in seropositive and seronegative healthcare workers undergoing COVID-19 mRNA …
Background: This study monitored total anti-SARS-CoV-2 (severe acute respiratory
syndrome coronavirus 2) RBD (receptor-binding domain) antibodies levels in a large …
syndrome coronavirus 2) RBD (receptor-binding domain) antibodies levels in a large …
SARS-CoV-2 quasispecies provides an advantage mutation pool for the epidemic variants
F Sun, X Wang, S Tan, Y Dan, Y Lu, J Zhang… - Microbiology …, 2021 - Am Soc Microbiol
The dynamics of quasispecies afford RNA viruses a great fitness on cell tropism and host
range. To study the quasispecies features and the intra-host evolution of SARS-CoV-2, we …
range. To study the quasispecies features and the intra-host evolution of SARS-CoV-2, we …
RNAs—a new frontier in crop protection
D Niu, R Hamby, JN Sanchez, Q Cai, Q Yan… - Current opinion in …, 2021 - Elsevier
Small RNA (sRNA)-mediated RNA interference (RNAi) is a regulatory mechanism
conserved in almost all eukaryotes. sRNAs play a critical role in host pathogen interactions …
conserved in almost all eukaryotes. sRNAs play a critical role in host pathogen interactions …