A systematic review of non-coding RNA therapeutics in early clinical trials: a new perspective against cancer
K Grillone, G Caridà, F Luciano, A Cordua… - Journal of Translational …, 2024 - Springer
Targeting non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-
coding RNAs (lncRNAs), has recently emerged as a promising strategy for treating …
coding RNAs (lncRNAs), has recently emerged as a promising strategy for treating …
[HTML][HTML] Redox Homeostasis, Gut Microbiota, and Epigenetics in Neurodegenerative Diseases: A Systematic Review
Neurodegenerative diseases encompass a spectrum of disorders marked by the
progressive degeneration of the structure and function of the nervous system. These …
progressive degeneration of the structure and function of the nervous system. These …
De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome
Around 60% of individuals with neurodevelopmental disorders (NDD) remain undiagnosed
after comprehensive genetic testing, primarily of protein-coding genes. Large genome …
after comprehensive genetic testing, primarily of protein-coding genes. Large genome …
Regulation of Zbp1 by miR-99b-5p in microglia controls the development of schizophrenia-like symptoms in mice
Current approaches to the treatment of schizophrenia have mainly focused on the protein-
coding part of the genome; in this context, the roles of microRNAs have received less …
coding part of the genome; in this context, the roles of microRNAs have received less …
Advances in the design and delivery of RNA vaccines for infectious diseases
RNA medicines represent a paradigm shift in treatment and prevention of critical diseases of
global significance, eg, infectious diseases. The highly successful messenger RNA (mRNA) …
global significance, eg, infectious diseases. The highly successful messenger RNA (mRNA) …
Cooperative application of transcriptomics and ceRNA hypothesis: lncRNA-00742/miR-116 targets CD74 to mediate vanadium-induced mitochondrial apoptosis in …
J Chen, X Dai, C Xing, Y Zhang, H Cao, G Hu… - Journal of Hazardous …, 2024 - Elsevier
Vanadium (V) is a poisonous metallic environmental pollutant which poses hazard to the
animal health of the liver. Competitive endogenous ribonucleic acids (ceRNAs) are essential …
animal health of the liver. Competitive endogenous ribonucleic acids (ceRNAs) are essential …
Unraveling the ncRNA landscape that governs colorectal cancer: A roadmap to personalized therapeutics
Colorectal cancer (CRC) being one of the most common malignancies, has a significant
death rate, especially when detected at an advanced stage. In most cases, the fundamental …
death rate, especially when detected at an advanced stage. In most cases, the fundamental …
Single-cell and spatial transcriptomics: Bridging current technologies with long-read sequencing
CU Yuan, FX Quah, M Hemberg - Molecular Aspects of Medicine, 2024 - Elsevier
Single-cell technologies have transformed biomedical research over the last decade,
opening up new possibilities for understanding cellular heterogeneity, both at the genomic …
opening up new possibilities for understanding cellular heterogeneity, both at the genomic …
Epigenetic dysregulation in the pathogenesis of systemic lupus erythematosus
Y Araki, T Mimura - International Journal of Molecular Sciences, 2024 - mdpi.com
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease in which immune
disorders lead to autoreactive immune responses and cause inflammation and tissue …
disorders lead to autoreactive immune responses and cause inflammation and tissue …
[HTML][HTML] Approaches to probe and perturb long noncoding RNA functions in diseases
Long noncoding RNAs (lncRNAs) are a class of RNA molecules exceeding 200 nucleotides
in length that lack long open-reading frames. Transcribed predominantly by RNA …
in length that lack long open-reading frames. Transcribed predominantly by RNA …