Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications

IP Trougakos, K Stamatelopoulos, E Terpos… - Journal of Biomedical …, 2021 - Springer
Background Gaining further insights into SARS-CoV-2 routes of infection and the underlying
pathobiology of COVID-19 will support the design of rational treatments targeting the life …

Pharmaco-immunomodulatory therapy in COVID-19

JG Rizk, K Kalantar-Zadeh, MR Mehra, CJ Lavie… - Drugs, 2020 - Springer
The severe acute respiratory syndrome coronavirus 2 associated coronavirus disease 2019
(COVID-19) illness is a syndrome of viral replication in concert with a host inflammatory …

Human immunology and immunotherapy: main achievements and challenges

J Varadé, S Magadán… - Cellular & Molecular …, 2021 - nature.com
The immune system is a fascinating world of cells, soluble factors, interacting cells, and
tissues, all of which are interconnected. The highly complex nature of the immune system …

The recent challenges of highly contagious COVID‐19, causing respiratory infections: Symptoms, diagnosis, transmission, possible vaccines, animal models, and …

RK Mohapatra, L Pintilie, V Kandi… - Chemical biology & …, 2020 - Wiley Online Library
COVID‐19 is highly contagious pathogenic viral infection initiated from Wuhan seafood
wholesale market of China on December 2019 and spread rapidly around the whole world …

Potential therapeutic targets and vaccine development for SARS-CoV-2/COVID-19 pandemic management: a review on the recent update

U Anand, S Jakhmola, O Indari, HC Jha… - Frontiers in …, 2021 - frontiersin.org
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly pathogenic
novel virus that has caused a massive pandemic called coronavirus disease 2019 (COVID …

Clinical efficacy of intravenous immunoglobulin therapy in critical ill patients with COVID‐19: a multicenter retrospective cohort study

Z Shao, Y Feng, L Zhong, Q Xie, M Lei… - Clinical & …, 2020 - Wiley Online Library
Abstract Objective Coronavirus disease 2019 (COVID‐19) outbreak is a major challenge all
over the world, without acknowledged treatment. Intravenous immunoglobulin (IVIG) has …

Non‐steroidal anti‐inflammatory drugs, prostaglandins, and COVID‐19

CT Robb, M Goepp, AG Rossi… - British Journal of …, 2020 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the cause of the novel
coronavirus disease 2019 (COVID‐19), a highly pathogenic and sometimes fatal respiratory …

Targeting human TLRs to combat COVID‐19: a solution?

R Patra, N Chandra Das… - Journal of medical …, 2021 - search.ebscohost.com
Targeting human TLRs to combat COVID-19: A solution? The recent publication by
Choudhury and Mukherjee1 in this journal depicted the interactions of severe acute …

Symptomatic protective action of glycyrrhizin (licorice) in COVID-19 infection?

H Murck - Frontiers in immunology, 2020 - frontiersin.org
The role of the ACE2 enzyme in the COVID-19 infection is 2-fold, with opposing implications
for the disease development. 1. The membrane bound angiotensin converting enzyme 2 …

Flattening the COVID-19 curve with natural killer cell based immunotherapies

M Market, L Angka, AB Martel, D Bastin… - Frontiers in …, 2020 - frontiersin.org
Natural Killer (NK) cells are innate immune responders critical for viral clearance and
immunomodulation. Despite their vital role in viral infection, the contribution of NK cells in …