Mechanobiology has underpinned many scientific advances in understanding how
biophysical and biomechanical cues regulate cell behavior by identifying mechanosensitive …

Adherent eukaryotic cells are subjected to a broad variety of extracellular and intracellular
stimuli regulating their behaviour. These stimuli can be either purely chemical, for example …

One of the most critical problems in heart valve tissue engineering is the progressive
development of valvular insufficiency due to leaflet retraction. Understanding the underlying …

Extracellular mechanical cues have been shown to have a profound effect on osteogenic
cell behaviour. However, it is not known precisely how these cues alter intracellular …

In this study we present a steady-state adaptation of the thermodynamically motivated stress
fiber (SF) model of Vigliotti et al.(2015). We implement this steady-state formulation in a non …

Chronic kidney diseases are widespread and incurable. The biophysical mechanisms
underlying them are unclear, in part because material systems for reconstituting the …

In the context of a mechanical approach to cell biology, there is a close relationship between
cellular function and mechanical properties. In recent years, an increasing amount of …

Tensional homeostasis is widely recognized to exist at the length scales of organs and
tissues, but the cellular length scale mechanism for tension regulation is not known. In this …

A bio-chemo-mechanical model is described that targets contractility, adhesion, signaling,
and cytoskeleton formation and remodeling, where the effort in the case of the last …

We present simulations of cell-cell adhesion as reported in a recent study [Liu et al., 2010,
PNAS, 107 (22), 9944-9] for two cells seeded on an array of micro-posts. The micro-post …