Epilepsy is a common neurological disorder that affects approximately 10.5 million children
worldwide. Approximately 33% of affected patients exhibit resistance to all available …

Background Pulmonary tuberculosis (PTB) is the most common type of tuberculosis (TB).
Rapid diagnosis of PTB can help in TB control. Although the use of molecular tests (such as …

Solid-state nanopores are a key platform for single-molecule detection and analysis that
allow engineering of their properties by controlling size, shape, and chemical …

Biological nanopores crucially control the import and export of biomolecules across lipid
membranes in cells. They have found widespread use in biophysics and biotechnology …

Metal centers are essential for enzyme catalysis, stabilizing the active site, facilitating
electron transfer, and maintaining the structure through coordination with amino acids. In this …

Single‐cell proteomics (SCP) aims to characterize the proteome of individual cells, providing
insights into complex biological systems. It reveals subtle differences in distinct cellular …

The transport of DNA polymers through nanoscale pores is central to many biological
processes, from bacterial gene exchange to viral infection. In single-molecule nanopore …

High-throughput proteomics has become an exciting field and a potential frontier of modern
medicine since the early 2000s. While significant progress has been made in the technical …

1. 中国科学院大学生命科学学院, 北京100049 2. 中国科学院杭州医学所组学与智慧医疗研究
中心, 杭州310022 3. 深圳华大生命科学研究院, 深圳518083 4. 沃森基因组科学研究院 …

The flaviviral NS2B/NS3 protease is a conserved enzyme required for flavivirus replication.
Its highly dynamic conformation poses major challenges but also offers opportunities for …