25 years of research in human lactation: from discovery to translation

DT Geddes, Z Gridneva, SL Perrella, LR Mitoulas… - Nutrients, 2021 - mdpi.com
Researchers have recently called for human lactation research to be conceptualized as a
biological framework where maternal and infant factors impacting human milk, in terms of …

[HTML][HTML] The hormonal physiology of immune components in breast milk and their impact on the infant immune response

MY Bermejo-Haro, RT Camacho-Pacheco… - Molecular and Cellular …, 2023 - Elsevier
During pregnancy, the maternal body undergoes a considerable transformation regarding
the anatomy, metabolism, and immune profile that, after delivery, allows for protection and …

[HTML][HTML] A human breast atlas integrating single-cell proteomics and transcriptomics

GK Gray, CMC Li, JM Rosenbluth, LM Selfors… - Developmental cell, 2022 - cell.com
The breast is a dynamic organ whose response to physiological and pathophysiological
conditions alters its disease susceptibility, yet the specific effects of these clinical variables …

Early-stage breast cancer detection in breast milk

C Saura, C Ortiz, J Matito, EJ Arenas, A Suñol, Á Martín… - Cancer discovery, 2023 - AACR
Breast cancer occurring during pregnancy (PrBC) and postpartum (PPBC) is usually
diagnosed at more advanced stages compared with other breast cancer, worsening its …

Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer

Y Zhang, MJ Wu, WC Lu, YC Li, CJ Chang, JY Yang - Cell Metabolism, 2024 - cell.com
Metabolic reprogramming is key for cancer development, yet the mechanism that sustains
triple-negative breast cancer (TNBC) cell growth despite deficient pyruvate kinase M2 …

Cellular and transcriptional diversity over the course of human lactation

SK Nyquist, P Gao, TKJ Haining… - Proceedings of the …, 2022 - National Acad Sciences
Human breast milk (hBM) is a dynamic fluid that contains millions of cells, but their identities
and phenotypic properties are poorly understood. We generated and analyzed single-cell …

A spatially resolved single-cell genomic atlas of the adult human breast

T Kumar, K Nee, R Wei, S He, QH Nguyen, S Bai… - Nature, 2023 - nature.com
The adult human breast is comprised of an intricate network of epithelial ducts and lobules
that are embedded in connective and adipose tissue,–. Although most previous studies have …

Bovine milk-derived cells express transcriptome markers of pluripotency and secrete bioactive factors with regenerative and antimicrobial activity

N Danev, RM Harman, L Oliveira, L Huntimer… - Scientific Reports, 2023 - nature.com
The bovine mammary stem/progenitor cell secretome stimulates regeneration in vitro and
contains proteins associated with antimicrobial defense. This has led to the exploration of …

Human milk lipids and small metabolites: Maternal and microbial origins

LF Stinson, AD George - Metabolites, 2023 - mdpi.com
Although there has been limited application in the field to date, human milk omics research
continues to gain traction. Human milk lipidomics and metabolomics research is particularly …

The mutational landscape of the adult healthy parous and nulliparous human breast

B Cereser, A Yiu, N Tabassum, L Del Bel Belluz… - Nature …, 2023 - nature.com
The accumulation of somatic mutations in healthy human tissues has been extensively
characterized, but the mutational landscape of the healthy breast is still poorly understood …