Targeting VIP and PACAP receptor signaling: new insights into designing drugs for the PACAP subfamily of receptors
Pituitary Adenylate Cyclase-Activating Peptide (PACAP) and Vasoactive Intestinal Peptide
(VIP) are neuropeptides involved in a diverse array of physiological and pathological …
(VIP) are neuropeptides involved in a diverse array of physiological and pathological …
Vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide, and their receptors and cancer
TW Moody, B Nuche-Berenguer… - Current Opinion in …, 2016 - journals.lww.com
VIP/PACAP has prominent growth effects on a number of common neoplasms, which
frequently overexpressed the three subtypes of their receptors. The increased …
frequently overexpressed the three subtypes of their receptors. The increased …
Alternative splicing of the pituitary adenylate cyclase-activating polypeptide receptor PAC1: mechanisms of fine tuning of brain activity
J Blechman, G Levkowitz - Frontiers in endocrinology, 2013 - frontiersin.org
Alternative splicing of the precursor mRNA encoding for the neuropeptide receptor
PAC1/ADCYAP1R1 generates multiple protein products that exhibit pleiotropic activities …
PAC1/ADCYAP1R1 generates multiple protein products that exhibit pleiotropic activities …
PACAP deficiency as a model of aging
Dysregulation of neuropeptides may play an important role in aging-induced impairments. In
the long list of neuropeptides, pituitary adenylate cyclase–activating polypeptide (PACAP) …
the long list of neuropeptides, pituitary adenylate cyclase–activating polypeptide (PACAP) …
[HTML][HTML] Targeted orexin and hypothalamic neuropeptides for migraine
LC Strother, A Srikiatkhachorn, W Supronsinchai - Neurotherapeutics, 2018 - Elsevier
The hypothalamus is involved in the regulation of homeostatic mechanisms and migraine-
related trigeminal nociception and as such has been hypothesized to play a central role in …
related trigeminal nociception and as such has been hypothesized to play a central role in …
Is PACAP the major neurotransmitter for stress transduction at the adrenomedullary synapse?
It has been known for more than a decade that the neuropeptide PACAP (pituitary adenylate
cyclase-activating polypeptide) is co-stored with acetylcholine in the splanchnic nerve …
cyclase-activating polypeptide) is co-stored with acetylcholine in the splanchnic nerve …
Pleiotropic pituitary adenylate cyclase-activating polypeptide (PACAP): Novel insights into the role of PACAP in eating and drug intake
Pituitary adenylate cyclase-activating polypeptide (PACAP) was discovered thirty years ago,
but its role in eating and drug use disorders has only recently begun to be investigated. The …
but its role in eating and drug use disorders has only recently begun to be investigated. The …
PACAP and acetylcholine cause distinct Ca2+ signals and secretory responses in chromaffin cells
The adrenomedullary chromaffin cell transduces chemical messages into outputs that
regulate end organ function throughout the periphery. At least two important …
regulate end organ function throughout the periphery. At least two important …
Pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal peptide [Part 1]: Biology, pharmacology, and new insights into their cellular basis of action …
Recent insights from studies of VIP/PACAP and their receptors in both central nervous
system disorders and inflammatory disorders suggest possible new treatment approaches …
system disorders and inflammatory disorders suggest possible new treatment approaches …
Pituitary adenylate cyclase activating polypeptide (PACAP) signalling exerts chondrogenesis promoting and protecting effects: implication of calcineurin as a …
Pituitary adenylate cyclase activating polypeptide (PACAP) is an important neurotrophic
factor influencing differentiation of neuronal elements and exerting protecting role during …
factor influencing differentiation of neuronal elements and exerting protecting role during …