Microglial inflammatory-metabolic pathways and their potential therapeutic implication in major depressive disorder
R Rahimian, C Belliveau, R Chen… - Frontiers in psychiatry, 2022 - frontiersin.org
Increasing evidence supports the notion that neuroinflammation plays a critical role in the
etiology of major depressive disorder (MDD), at least in a subset of patients. By virtue of their …
etiology of major depressive disorder (MDD), at least in a subset of patients. By virtue of their …
Therapeutic strategies for treatment of inflammation-related depression
Background: Mounting evidence demonstrates enhanced systemic levels of inflammatory
mediators in depression, indicating that inflammation may play a role in the etiology and …
mediators in depression, indicating that inflammation may play a role in the etiology and …
Incident major depressive disorder predicted by three measures of insulin resistance: a Dutch cohort study
Objective: Major depressive disorder is the leading cause of disability worldwide. Yet, there
remain significant challenges in predicting new cases of major depression and devising …
remain significant challenges in predicting new cases of major depression and devising …
Apigenin ameliorates chronic mild stress-induced depressive behavior by inhibiting interleukin-1β production and NLRP3 inflammasome activation in the rat brain
R Li, X Wang, T Qin, R Qu, S Ma - Behavioural brain research, 2016 - Elsevier
Increasing evidence suggests that inflammation and oxidative stress may contribute to the
development of major depressive disorder (MDD). Apigenin, a type of bioflavonoid widely …
development of major depressive disorder (MDD). Apigenin, a type of bioflavonoid widely …
Role of the adipose PPARγ-adiponectin axis in susceptibility to stress and depression/anxiety-related behaviors
M Guo, C Li, Y Lei, S Xu, D Zhao, XY Lu - Molecular psychiatry, 2017 - nature.com
Adaptive responses to stressful stimuli involving behavioral, emotional and metabolic
changes are orchestrated by the nervous and endocrine systems. Adipose tissue has been …
changes are orchestrated by the nervous and endocrine systems. Adipose tissue has been …
The antidepressant-like effects of pioglitazone in a chronic mild stress mouse model are associated with PPARγ-mediated alteration of microglial activation …
Background Discoveries that microglia-mediated neuroinflammation is involved in the
pathological process of depression provided a new strategy for novel antidepressant …
pathological process of depression provided a new strategy for novel antidepressant …
Pioglitazone adjunctive therapy for moderate-to-severe major depressive disorder: randomized double-blind placebo-controlled trial
K Sepanjnia, A Modabbernia, M Ashrafi… - …, 2012 - nature.com
Thiazolidinediones have shown antidepressant effect in animal studies, as well as in some
uncontrolled studies evaluating human subjects with concurrent major depressive disorder …
uncontrolled studies evaluating human subjects with concurrent major depressive disorder …
Co-occurrence of anxiety and depressive-like behaviors following adolescent social isolation in male mice; possible role of nitrergic system
Approximately more than 50% of patients with depression have the co-occurrence of
anxiety, which complicates the treatment of disease. Recently, social isolation stress (SIS) …
anxiety, which complicates the treatment of disease. Recently, social isolation stress (SIS) …
Pioglitazone adjunctive therapy for depressive episode of bipolar disorder: a randomized, double‐blind, placebo‐controlled trial
A Zeinoddini, M Sorayani, E Hassanzadeh… - Depression and …, 2015 - Wiley Online Library
Background The antidepressive effect of pioglitazone has been noted in patients with major
depressive disorder in absence of metabolic syndrome. This study was conducted to …
depressive disorder in absence of metabolic syndrome. This study was conducted to …
Pathological parainflammation and endoplasmic reticulum stress in depression: potential translational targets through the CNS insulin, klotho and PPAR-γ systems
Major depression and bipolar disorder are heterogeneous conditions in which there can be
dysregulation of (1) the stress system response,(2) its capacity for counterregulation after …
dysregulation of (1) the stress system response,(2) its capacity for counterregulation after …