New insights into molecules and pathways of cancer metabolism and therapeutic implications

Z Tang, Z Xu, X Zhu, J Zhang - Cancer Communications, 2021 - Wiley Online Library
Cancer cells are abnormal cells that can reproduce and regenerate rapidly. They are
characterized by unlimited proliferation, transformation and migration, and can destroy …

Extracellular vesicle-based liquid biopsy biomarkers and their application in precision immuno-oncology

K Asleh, V Dery, C Taylor, M Davey… - Biomarker …, 2023 - Springer
While the field of precision oncology is rapidly expanding and more targeted options are
revolutionizing cancer treatment paradigms, therapeutic resistance particularly to …

[HTML][HTML] Blood biomarkers for differential diagnosis and early detection of pancreatic cancer

FN Al-Shaheri, MSS Alhamdani, AS Bauer… - Cancer treatment …, 2021 - Elsevier
Pancreatic cancer is currently the most lethal tumor entity and case numbers are rising. It will
soon be the second most frequent cause of cancer-related death in the Western world …

Biomarkers for pancreatic cancer based on tissue and serum metabolomics analysis in a multicenter study

R Zhao, S Ren, C Li, K Guo, Z Lu, L Tian, J He… - Cancer …, 2023 - Wiley Online Library
Background Early detection of pancreatic ductal adenocarcinoma (PDAC) may improve the
prognosis of patients. This study was to identify metabolic features of PDAC and to discover …

Plasma metabolomics predicts chemotherapy response in advanced pancreatic cancer

H Muranaka, A Hendifar, A Osipov, N Moshayedi… - Cancers, 2023 - mdpi.com
Simple Summary Pancreatic cancer is a clinically heterogeneous disease, and treatment
leads to different outcomes for people with similar diagnoses. Identifying patients who may …

Meta-analysis reveals both the promises and the challenges of clinical metabolomics

HE Roth, R Powers - Cancers, 2022 - mdpi.com
Simple Summary A highly desirable approach to diagnose a human disease quickly and
easily is to identify a chemical, protein, or antibody in a biofluid like blood or urine that is …

A unique urinary metabolomic signature for the detection of pancreatic ductal adenocarcinoma

S Sahni, AR Pandya, WJ Hadden… - … Journal of Cancer, 2021 - Wiley Online Library
Our study aimed to identify a urinary metabolite panel for the detection/diagnosis of
pancreatic ductal adenocarcinoma (PDAC). PDAC continues to have poor survival …

[HTML][HTML] Bioinformatics analysis identified MMP14 and COL12A1 as immune-related biomarkers associated with pancreatic adenocarcinoma prognosis

Y Li, Z Su, B Wei, M Qin, Z Liang - Mathematical Biosciences and …, 2021 - aimspress.com
Pancreatic adenocarcinoma (PAAD) is one of the most common malignant tumors with high
mortality rates and a poor prognosis. There is an urgent need to determine the molecular …

Potential metabolite biomarkers for early detection of stage-I pancreatic ductal adenocarcinoma

Y Cao, R Zhao, K Guo, S Ren, Y Zhang, Z Lu… - Frontiers in …, 2022 - frontiersin.org
Background & Objectives Pancreatic ductal adenocarcinoma remains an extremely
malignant tumor having a poor prognosis. The 5-year survival rate of PDAC is related to its …

The bacterial metabolite, lithocholic acid, has antineoplastic effects in pancreatic adenocarcinoma

S Schwarcz, P Kovács, P Nyerges, G Ujlaki… - Cell Death …, 2024 - nature.com
Lithocholic acid (LCA) is a secondary bile acid. LCA enters the circulation after bacterial
synthesis in the gastrointestinal tract, reaches distantly located cancer cells, and influences …