Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …

The future development of personalized medicine depends on a vast exchange of data from
different sources, as well as harmonized integrative analysis of large-scale clinical health …

Medicine and healthcare are undergoing profound changes. Whole-genome sequencing
and high-resolution imaging technologies are key drivers of this rapid and crucial …

Monitoring and modeling biomedical, health care and wellness data from individuals and
converging data on a population scale have tremendous potential to improve understanding …

Introduction: This article is part of the Focus Theme of Methods of Information in Medicine on
the German Medical Informatics Initiative.“Smart Medical Information Technology for …

The emerging concept of systems medicine (or 'P4 medicine'—predictive, preventive,
personalized and participatory) is at the vanguard of the post-genomic movement towards …

Many common diseases, such as asthma, diabetes or obesity, involve altered interactions
between thousands of genes. High-throughput techniques (omics) allow identification of …

Objective: Modern medicine needs to shift from a wait and react, curative discipline to a
preventative, interdisciplinary science aiming at providing personalized, systemic, and …

The 'precision medicine (systems medicine)'concept promises to achieve a shift to future
healthcare systems with a more proactive and predictive approach to medicine, where the …

Innovative biologics, including cell therapeutics, virus-like particles, exosomes, recombinant
proteins, and peptides, seem likely to substitute monoclonal antibodies as the main …